Mopride Tablet 2 mg contains Prucalopride Succinate, a highly selective serotonin (5-HT₄) receptor agonist used for the treatment of chronic constipation in adult patients who have not achieved satisfactory relief with conventional laxatives. By directly stimulating gastrointestinal motility, Mopride helps restore normal bowel function and improves overall digestive comfort.

This medicine is suitable for long-term use under medical supervision and is especially beneficial for patients suffering from persistent constipation that significantly affects quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Mopride Tablet 2 mg is indicated for:

• Treatment of chronic idiopathic constipation in adults

• Patients with inadequate response to traditional laxative therapy

• Improvement of bowel movement frequency and stool consistency

Therapeutic Class

• Gastrointestinal prokinetic agent

• Selective serotonin (5-HT₄) receptor agonist

Pharmacology and Mode of Action

Prucalopride acts as a highly selective 5-HT₄ receptor agonist in the gastrointestinal tract. Activation of these receptors enhances colonic peristalsis, the coordinated muscle contractions responsible for moving stool through the colon.

By accelerating intestinal transit, Mopride Tablet 2 mg reduces stool retention and facilitates regular bowel movements. Its selectivity for 5-HT₄ receptors minimizes interaction with other serotonin receptors, contributing to a favorable safety profile and reducing the risk of cardiovascular side effects associated with earlier prokinetic drugs.

Dosage and Administration

• Recommended adult dose: 2 mg once daily

• Tablets may be taken with or without food, preferably at the same time each day

Special Populations:

• Elderly patients: A lower starting dose may be considered based on clinical judgment

• Renal impairment: Dose reduction may be necessary in severe renal dysfunction

• Hepatic impairment: No dose adjustment is usually required in mild to moderate hepatic impairment

Treatment duration should be determined by the treating physician based on individual response.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Prucalopride has minimal potential for drug interactions. It does not significantly affect cytochrome P450 enzymes and is unlikely to interfere with most commonly prescribed medications. Nonetheless, patients should inform their healthcare provider about all medicines they are taking, particularly drugs that influence bowel motility or electrolyte balance.

Contraindications

Mopride Tablet 2 mg should not be used in patients with:

• Hypersensitivity to Prucalopride or any tablet component

• Intestinal obstruction or perforation

• Severe inflammatory bowel disease

Side Effects

Common side effects may include:

• Headache

• Abdominal pain or cramps

• Nausea

• Diarrhea

• Dizziness

These reactions are usually mild to moderate and often occur at the start of therapy, with many resolving as treatment continues.

Rare side effects:

• Palpitations

• Mood changes or anxiety

If side effects persist or worsen, medical advice should be sought.

Pregnancy and Lactation

There is limited clinical data on the use of Prucalopride during pregnancy. Mopride Tablet 2 mg should be used in pregnant women only if clearly needed. Caution is also advised during breastfeeding, as information on excretion into human milk is insufficient.

Precautions and Warnings

• Not indicated for acute constipation or bowel obstruction

• Adequate fluid intake and dietary fiber should be maintained

• Discontinue treatment and consult a physician if severe diarrhea or abdominal pain develops

Storage Conditions

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.