Nevalto Tablet is a fixed-dose combination of Nebivolol 5 mg and Valsartan 80 mg, formulated for the effective management of hypertension. By combining a selective beta-1 adrenergic blocker with an angiotensin II receptor blocker (ARB), Nevalto provides dual-mechanism blood pressure control. This combination helps achieve better and more sustained reduction in blood pressure while improving cardiovascular outcomes and patient adherence.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Antihypertensive agents
(Beta-blocker + Angiotensin II receptor blocker)

Indications

Nevalto Tablet is indicated for the treatment of:

• Essential hypertension

• Patients whose blood pressure is not adequately controlled with monotherapy

• Reduction of cardiovascular risk associated with persistent high blood pressure

It is suitable for patients requiring combination therapy to achieve optimal blood pressure targets.

Pharmacology

• Nebivolol: A highly selective beta-1 adrenergic receptor blocker that reduces heart rate and myocardial contractility, leading to decreased cardiac output. Nebivolol also enhances nitric oxide-mediated vasodilation, improving endothelial function and peripheral blood flow.

• Valsartan: An angiotensin II receptor blocker that selectively inhibits the AT1 receptor, preventing vasoconstriction and aldosterone secretion. This results in vasodilation, reduced sodium and water retention, and lowered blood pressure.

The complementary actions of nebivolol and valsartan provide effective blood pressure reduction with a favorable tolerability profile.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

The usual recommended dose of Nevalto Tablet is one tablet once daily, or as directed by a physician.

• It may be taken with or without food.

• Dosage adjustment should be based on blood pressure response and patient tolerability.

• Patients should take the tablet at the same time each day for optimal blood pressure control.

Dose modification may be required in elderly patients or those with renal or hepatic impairment.

Contraindications

Nevalto Tablet is contraindicated in patients with:

• Hypersensitivity to nebivolol, valsartan, or any component of the formulation

• Severe bradycardia, heart block, or cardiogenic shock

• Severe hepatic impairment

• Pregnancy, especially during the second and third trimesters

Side Effects

Commonly reported side effects may include:

• Headache

• Dizziness or lightheadedness

• Fatigue

• Bradycardia

• Hypotension

Most adverse effects are mild to moderate and often diminish with continued treatment.

Precautions and Warnings

Caution is advised in patients with heart failure, renal artery stenosis, electrolyte imbalance, or impaired renal function. Sudden discontinuation of beta-blockers should be avoided to prevent rebound hypertension or angina. Blood pressure, heart rate, and renal function should be monitored regularly during therapy.

Pregnancy and Lactation

Nevalto Tablet is contraindicated during pregnancy due to the risk of fetal toxicity associated with valsartan. Breastfeeding mothers should use this medication only if clearly needed and under medical supervision.

Storage Conditions

Store in a cool, dry place below 30°C, protected from light and moisture. Keep out of reach of children.