Numira Tablet 2.5 mg contains Mirogabalin Besylate, a novel and selective ligand of the α2δ subunit of voltage-gated calcium channels. It is primarily used for the management of neuropathic pain, a chronic and often debilitating condition resulting from nerve damage or dysfunction. Numira Tablet is formulated to provide effective pain relief with improved tolerability and sustained therapeutic action.

Mirogabalin is known for its strong binding affinity and prolonged action at the α2δ-1 subunit, which plays a key role in pain transmission. This targeted mechanism helps reduce abnormal neuronal excitability, thereby alleviating pain symptoms and improving quality of life in patients suffering from neuropathic disorders.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন 

Indications

Numira Tablet 2.5 mg is indicated for the treatment of:

• Peripheral neuropathic pain

• Diabetic peripheral neuropathy

• Postherpetic neuralgia

• Other neuropathic pain conditions as determined by the physician

Therapeutic Class

Neuropathic Pain Modulator / Anticonvulsant (α2δ Ligand)

Pharmacology / Mode of Action

Mirogabalin Besylate exerts its pharmacological effect by selectively binding to the α2δ subunits (α2δ-1 and α2δ-2) of voltage-gated calcium channels in the central nervous system. By inhibiting calcium influx into presynaptic neurons, it reduces the release of excitatory neurotransmitters such as glutamate, substance P, and norepinephrine.

This reduction in neurotransmitter release decreases neuronal hyperexcitability and interrupts pain signaling pathways. Compared to other agents in its class, Mirogabalin demonstrates sustained receptor binding, which contributes to prolonged analgesic efficacy and a lower incidence of central nervous system side effects.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন 

Dosage & Administration

The dosage of Numira Tablet 2.5 mg should be individualized based on patient response, severity of symptoms, and renal function.

• Tablets are taken orally, with or without food

• Treatment is usually initiated at a low dose and titrated gradually

• Dose adjustment may be required in patients with renal impairment

Patients should follow the dosing instructions provided by their healthcare professional and should not discontinue therapy abruptly.

Drug Interactions

Caution is advised when Numira Tablet is used with:

• Central nervous system depressants such as sedatives, opioids, or alcohol, due to increased risk of dizziness or drowsiness

No major clinically significant drug interactions have been commonly reported.

Contraindications

Numira Tablet 2.5 mg is contraindicated in patients with known hypersensitivity to Mirogabalin Besylate or any component of the formulation.

Side Effects

Commonly reported side effects may include:

• Dizziness

• Somnolence

• Headache

• Weight gain

• Peripheral edema

These side effects are generally mild to moderate and tend to decrease with continued use.

Pregnancy & Lactation

There are limited data regarding the use of Mirogabalin during pregnancy and lactation. Numira Tablet should be used during pregnancy only if the potential benefit justifies the potential risk. Caution is advised when prescribing to breastfeeding mothers.

Precautions & Warnings

• Use with caution in patients with renal impairment

• Patients should avoid activities requiring mental alertness if dizziness or drowsiness occurs

• Gradual dose tapering is recommended when discontinuing therapy

Storage Conditions

Store in a cool and dry place, protected from light and moisture. Keep out of the reach of children.