Palker Capsule 125 mg contains Palbociclib, an oral targeted anticancer medicine belonging to the class of CDK4/6 inhibitors. It is used mainly in the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. Palbociclib works by slowing down the growth and division of cancer cells, helping to control disease progression.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Palbociclib
• Strength: 125 mg per capsule

Mechanism of Action

Palbociclib selectively inhibits cyclin-dependent kinases 4 and 6 (CDK4/6), which are responsible for regulating cell cycle progression. By blocking these enzymes, it prevents cancer cells from entering the DNA synthesis phase (G1 to S phase transition), thereby slowing tumor growth and reducing cancer cell proliferation.

Indications

Palker Capsule 125 mg is indicated for:

• Hormone receptor-positive, HER2-negative advanced or metastatic breast cancer
• Use in combination with aromatase inhibitors or fulvestrant
• First-line or subsequent therapy in eligible patients as prescribed by an oncologist

Dosage and Administration

• Taken orally once daily for 21 consecutive days followed by 7 days off (28-day cycle), or as directed by an oncologist
• Should be taken at the same time each day
• Can be taken with or without food
• Capsule should be swallowed whole, not crushed or opened

Benefits

• Slows progression of hormone receptor-positive breast cancer
• Enhances effectiveness of endocrine therapy
• Helps delay disease progression
• Oral administration improves patient convenience
• Provides targeted action with improved treatment outcomes

Possible Side Effects

Common side effects may include:

• Neutropenia (low white blood cell count)
• Fatigue
• Nausea
• Hair thinning
• Mouth ulcers
• Diarrhea

Serious side effects may include infections due to low immunity. Regular blood monitoring is essential.

Precautions and Warnings

• Must be used under strict oncology supervision
• Regular complete blood count (CBC) monitoring is required
• Avoid use during pregnancy and breastfeeding
• Use caution in patients with liver impairment
• Inform the doctor about all medications being taken

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store in a cool and dry place
• Protect from moisture and light
• Keep out of reach of children

Conclusion

Palker Capsule 125 mg (Palbociclib) is an advanced targeted therapy used for hormone receptor-positive breast cancer. It helps slow cancer cell growth and improve treatment outcomes when used as part of a comprehensive oncology regimen under specialist supervision.