Palnox Tablet 0.5 mg contains Palonosetron, a selective 5-HT3 receptor antagonist used to prevent and manage nausea and vomiting associated with chemotherapy, radiotherapy, and surgery. Palonosetron works by blocking serotonin (5-HT3) receptors in the gastrointestinal tract and central nervous system, which are key mediators in triggering the vomiting reflex.

As an oral formulation, Palnox Tablet 0.5 mg offers a convenient and non-invasive option for patients who may prefer tablets over injections. Its long half-life allows for extended protection against both acute (within 24 hours) and delayed (24–120 hours) emesis, making it highly effective in preventing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Palnox Tablet 0.5 mg is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (CINV): Particularly in patients undergoing moderately to highly emetogenic chemotherapy.

• Prevention of postoperative nausea and vomiting (PONV): Reduces nausea and vomiting following surgical procedures.

• Prevention of radiotherapy-induced nausea and vomiting: In patients undergoing radiotherapy with a high emetogenic risk.

It is intended for adult use under the guidance of a physician and is usually part of a comprehensive antiemetic regimen.

Key Benefits

• Effective antiemetic: Blocks serotonin receptors to prevent nausea and vomiting efficiently.

• Long-acting protection: Reduces the need for multiple doses by covering both acute and delayed emesis.

• Convenient oral administration: Easy-to-take tablet suitable for outpatient therapy.

• Well-tolerated: Minimal sedative effects compared to other antiemetics.

• Improves patient comfort: Enhances adherence to chemotherapy or radiotherapy schedules by controlling emesis.

Palnox Tablet 0.5 mg provides safe, reliable, and convenient control of nausea and vomiting, supporting patients through treatment and recovery.

Dosage and Administration

• Recommended dose: Typically, 0.5 mg taken orally approximately 30 minutes before chemotherapy or surgical procedure.

• Swallow the tablet whole with water; do not crush or chew.

• For highly emetogenic chemotherapy, additional antiemetics such as dexamethasone may be used in combination.

• No routine dose adjustment is required for mild to moderate renal or hepatic impairment, but caution is advised for severe conditions.

• Adherence to the prescribed schedule is important for optimal protection against nausea and vomiting.

Precautions

• Avoid in patients with known hypersensitivity to Palonosetron or other 5-HT3 antagonists.

• Use caution in patients with cardiac arrhythmias, prolonged QT interval, or electrolyte imbalances, as rare cardiac effects may occur.

• Inform your doctor about all other medications to avoid potential drug interactions.

• Pregnant or breastfeeding women should take the drug only under medical supervision.

• Discontinue if severe allergic reactions or significant side effects occur.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Palnox Tablet 0.5 mg is generally well tolerated. Common side effects include:

• Headache or mild dizziness

• Constipation

• Fatigue or mild weakness

• Flushing or transient warmth

Rare but serious side effects may include:

• Severe hypersensitivity reactions (rash, swelling, difficulty breathing)

• Cardiac arrhythmias or QT interval prolongation

• Severe constipation or gastrointestinal obstruction

Seek immediate medical care if serious symptoms appear.

Storage Instructions

• Store at below 25°C in a cool, dry place.

• Keep the tablets in the original packaging to protect from moisture and light.

• Keep out of reach of children.

• Do not use after the expiration date printed on the packaging.

Palnox Tablet 0.5 mg (Palonosetron) is a reliable, convenient, and effective oral antiemetic for preventing nausea and vomiting associated with chemotherapy, radiotherapy, and surgical procedures, enhancing patient comfort and treatment adherence.