Pangesic Tablet 325 mg + 37.5 mg is a combination analgesic containing Paracetamol (325 mg) and Tramadol Hydrochloride (37.5 mg). This dual-action formulation is designed for the effective management of moderate to moderately severe pain, providing both rapid and sustained relief.

Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system, reducing pain and fever. Tramadol Hydrochloride is a centrally acting opioid analgesic that binds to opioid receptors in the brain and spinal cord, modifying the perception and response to pain. Together, these agents provide synergistic pain relief, targeting different mechanisms of pain transmission.

Pangesic is suitable for a variety of acute and chronic pain conditions, including post-surgical pain, musculoskeletal pain, dental pain, and painful medical procedures. The tablet formulation ensures convenient oral administration and reliable dosing for adults.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features

• Contains Paracetamol 325 mg + Tramadol Hydrochloride 37.5 mg per tablet

• Dual-action analgesic for moderate to moderately severe pain

• Combines non-opioid and opioid mechanisms for enhanced pain relief

• Fast-acting and long-lasting effects

• Oral tablet for convenient administration

• Suitable for various acute and chronic pain conditions

Indications

Pangesic Tablet 325 mg + 37.5 mg is indicated for:

• Postoperative pain: Relief following surgical procedures

• Musculoskeletal pain: Including strains, sprains, and back pain

• Dental pain: Toothache or pain after dental procedures

• Chronic pain: When moderate pain requires combination therapy

• Other acute pain conditions where single-agent analgesics are insufficient

Mechanism of Action

• Paracetamol: Inhibits prostaglandin synthesis in the brain, reducing pain signals and lowering fever

• Tramadol Hydrochloride: Binds to mu-opioid receptors in the central nervous system and inhibits the reuptake of serotonin and norepinephrine, modifying pain perception and response

This complementary mechanism provides rapid onset and sustained analgesia while reducing the total dose of opioids required.

Dosage and Administration

• Adults: Typically 1–2 tablets every 6–8 hours as needed for pain

• Do not exceed 8 tablets in 24 hours

• Swallow tablets whole with water; do not crush or chew

• Adjustments may be required in patients with liver or kidney impairment

• Use for the shortest duration necessary to relieve pain

Possible Side Effects

Common side effects may include:

• Dizziness or drowsiness

• Nausea or vomiting

• Constipation

• Headache

• Sweating or mild fatigue

Serious side effects (rare) may include:

• Respiratory depression

• Allergic reactions

• Seizures in predisposed individuals

• Severe hypotension

Patients should seek medical attention if they experience difficulty breathing, severe allergic reactions, or other serious symptoms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use under medical supervision, particularly in patients with respiratory disorders, liver or kidney disease, or a history of seizures

• Avoid alcohol and other CNS depressants while taking Pangesic

• Not recommended during pregnancy or breastfeeding unless advised by a doctor

• Risk of dependence with prolonged use of Tramadol

• Inform your doctor of all other medications to prevent interactions

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep tablets in the original container, tightly closed

• Keep out of reach of children.