Pedeamin 100 ml is an oral liquid formulation containing Diphenhydramine Hydrochloride, a first-generation sedating antihistamine. It is widely used for the symptomatic treatment of various allergic and hypersensitivity conditions. Due to its antihistaminic, anticholinergic, and sedative properties, Pedeamin is also useful in managing motion sickness, nausea, and certain neurological conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Pedeamin 100 ml is indicated for the treatment and management of the following conditions:

• Seasonal, perennial, and vasomotor rhinitis

• Urticaria (hives) and other allergic skin conditions

• Angioneurotic oedema and anaphylactic reactions (as adjunct therapy)

• Pruritic conditions of allergic origin

• Premedication for prevention of emesis and motion sickness

• Miscellaneous conditions such as Meniere’s disease and parkinsonism

Therapeutic Class

Sedating Antihistamine

Pharmacology

Diphenhydramine is an H1-receptor antagonist with significant anticholinergic and sedative effects. It works by competitively inhibiting histamine at H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. By blocking histamine-mediated responses, it reduces symptoms such as itching, sneezing, rhinorrhea, and swelling associated with allergic reactions. Its central nervous system depressant action contributes to its sedative and antiemetic effects.

Dosage and Administration

Adults:

• For most allergic conditions: 25–50 mg three times daily, with an additional 50 mg at night if required

Children:

• 1 to 5 years: 5 mg (2.5 ml of elixir) four times daily

• Above 6 years: 10 mg (5 ml of elixir) four times daily

Dosage should be adjusted according to patient response and under medical supervision.

Drug Interactions

• Diphenhydramine may reduce the gastrointestinal absorption of para-aminosalicylic acid (PAS)

• Concomitant use with CNS depressants (such as sedatives, alcohol, or tranquilizers) may enhance sedative effects

• Anticholinergic drugs may potentiate anticholinergic adverse reactions

Contraindications

• Known hypersensitivity to Diphenhydramine or any component of the formulation

• Ammonium chloride-containing formulations are contraindicated in patients with impaired hepatic or renal function

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects may include:

• Sedation and drowsiness

• Dizziness and fatigue

• Tinnitus

• Ataxia

• Blurred vision or diplopia

• Euphoria

• Epigastric discomfort

Pregnancy and Lactation

Pregnancy Category B:
There are no adequate and well-controlled studies in pregnant women. Pedeamin 100 ml should be used during pregnancy only if clearly needed. Diphenhydramine is excreted in breast milk; therefore, its use is not recommended in lactating mothers.

Precautions and Warnings

Caution is advised in patients where drowsiness may be hazardous, such as drivers and machine operators. Alcohol and other CNS depressants should be avoided as they may potentiate sedation.

Overdose

Symptoms: Impaired consciousness, psychosis, seizures, antimuscarinic effects (mydriasis, tachycardia, tachyarrhythmias), respiratory failure, rhabdomyolysis, and acute delirium with hallucinations.
Management: Supportive and symptomatic treatment. Severe CNS stimulation or convulsions may be managed with intravenous diazepam.

Storage Conditions

Store between 15°C and 30°C. Protect from moisture and keep out of reach of children.