Pendoril Plus Tablet 2 mg + 0.625 mg is a combination antihypertensive therapy containing Perindopril (2 mg) and Indapamide (0.625 mg). This formulation is designed to effectively manage high blood pressure (hypertension) while providing added cardiovascular protection.

Perindopril is an ACE inhibitor that relaxes blood vessels, reduces blood pressure, and decreases the workload on the heart. Indapamide is a thiazide-like diuretic that helps remove excess sodium and water from the body, reducing fluid volume and lowering blood pressure. Together, these agents provide synergistic effects for better blood pressure control than either component alone.

Pendoril Plus is particularly suitable for patients who require mild to moderate antihypertensive therapy or those who need combination therapy to achieve target blood pressure levels. The low-dose formulation ensures tolerability and flexibility in treatment.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features

• Contains Perindopril 2 mg + Indapamide 0.625 mg per tablet

• Combination therapy for effective blood pressure control

• Relaxes blood vessels and promotes fluid elimination

• Protects the heart, kidneys, and vascular system

• Oral tablet for convenient once-daily dosing

• Suitable for mild to moderate hypertension or initial combination therapy

Indications

Pendoril Plus Tablet 2 mg + 0.625 mg is indicated for:

• Hypertension: To achieve optimal blood pressure control

• Cardiovascular risk reduction: Particularly in patients at risk of heart attack or stroke

• Edema management: Mild fluid retention associated with hypertension

• Patients requiring combination therapy: When monotherapy with ACE inhibitors or diuretics is insufficient

Mechanism of Action

• Perindopril (ACE inhibitor): Inhibits the conversion of angiotensin I to angiotensin II, leading to vasodilation, reduced aldosterone secretion, and lower blood pressure. It also protects the heart and kidneys from hypertension-related damage.

• Indapamide (thiazide-like diuretic): Increases the excretion of sodium and water through the kidneys, reducing blood volume and contributing to decreased blood pressure. It also has a mild vasodilatory effect.

The combination provides complementary actions to effectively lower blood pressure while protecting vital organs.

Dosage and Administration

• Recommended dose: 1 tablet orally once daily

• Can be taken with or without food, preferably at the same time each day

• Blood pressure should be monitored regularly

• Dose adjustments may be necessary for patients with kidney or liver impairment

• Suitable as initial therapy or in patients requiring step-up therapy from monotherapy

Possible Side Effects

Common side effects:

• Dizziness or lightheadedness, especially after the first dose

• Fatigue or weakness

• Headache

• Mild cough

• Increased urination

Rare but serious side effects:

• Severe hypotension

• Angioedema (swelling of face, lips, or throat)

• Electrolyte imbalances (low potassium or sodium)

• Kidney dysfunction

Patients should seek immediate medical attention if they experience severe swelling, difficulty breathing, fainting, or persistent electrolyte-related symptoms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Use under medical supervision, especially in patients with kidney or liver impairment

• Regular monitoring of blood pressure, kidney function, and electrolytes is recommended

• Avoid use during pregnancy or breastfeeding

• Inform your healthcare provider about all other medications to prevent interactions

• Caution in patients taking other diuretics, ACE inhibitors, or antihypertensive agents

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from light and moisture

• Keep tablets in the original container, tightly closed

• Keep out of reach of children.