Pentasa Microgranules 1 gm/sachet contains Mesalazine (5-aminosalicylic acid or 5-ASA), an anti-inflammatory medicine used in the management of inflammatory bowel diseases (IBD). The microgranule formulation is designed for prolonged release, allowing the active ingredient to be delivered throughout the small and large intestine for effective local action.

Mesalazine works directly on the intestinal lining to reduce inflammation, relieve symptoms, and help maintain remission in chronic inflammatory conditions of the bowel.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Reduces intestinal inflammation

• Helps control symptoms such as diarrhea, abdominal pain, and rectal bleeding

• Supports maintenance of remission in ulcerative colitis

• Prolonged-release microgranule formulation for targeted intestinal action

• Suitable for long-term management under medical supervision

Indications

Pentasa Microgranules 1 gm/sachet is indicated for:

• Mild to moderate ulcerative colitis

• Maintenance of remission in ulcerative colitis

• Crohn’s disease involving the small intestine and colon

• Other inflammatory bowel conditions as prescribed by a physician.

Dosage and Administration

• The usual adult dosage varies depending on the severity of the condition.

• Commonly prescribed as 1–4 gm daily in divided doses, according to medical advice.

• The contents of the sachet may be taken directly on the tongue and swallowed with water, or mixed with a small amount of water or soft food.

• Do not crush or chew the microgranules, as this may affect the prolonged-release mechanism.

Always follow your healthcare provider’s instructions regarding dosage and duration.

Mechanism of Action

Mesalazine acts locally in the intestinal mucosa. It works by:

• Inhibiting the production of inflammatory mediators such as prostaglandins and leukotrienes

• Reducing cytokine activity

• Decreasing oxidative stress in the intestinal lining

These actions help reduce inflammation and promote healing of the intestinal mucosa.

Safety Information

Contraindications:

• Hypersensitivity to mesalazine, salicylates, or any component of the formulation

• Severe renal impairment

Warnings and precautions:

• Renal function should be monitored before and during treatment

• Use cautiously in patients with liver impairment

• Rare risk of blood disorders; periodic blood count monitoring may be required

• Inform your doctor if you experience worsening abdominal pain, fever, or rash

Common side effects may include:

• Headache

• Nausea

• Abdominal pain

• Diarrhea

Serious side effects are rare but require immediate medical attention.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.