Pregan ER Tablet 82.5 mg contains Pregabalin in an extended-release (ER) formulation. It is used for the management of neuropathic pain and certain neurological conditions. The extended-release form provides a gradual and sustained release of medicine, helping maintain stable drug levels in the body and improving symptom control throughout the day.

Pregabalin works by calming overactive nerve signals, thereby reducing pain sensations and improving quality of life in patients with chronic nerve-related conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Pregan ER Tablet 82.5 mg is indicated for:

• Neuropathic pain (diabetic neuropathy, post-herpetic neuralgia)
• Peripheral nerve pain
• Chronic nerve-related pain conditions
• Fibromyalgia (as prescribed)
• Adjunct therapy in partial seizures (epilepsy)
• Generalized anxiety disorder (in selected cases as prescribed)

Mechanism of Action

Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. As a result, it decreases abnormal nerve activity, helping to relieve pain, reduce seizure frequency, and stabilize nerve signaling.

The ER formulation ensures slow and steady absorption, providing prolonged therapeutic effects.

Dosage and Administration

• Take only as prescribed by a physician
• Usually taken once daily due to extended-release formulation
• Swallow the tablet whole with water; do not crush or chew
• Can be taken with or without food
• Do not discontinue suddenly; dose should be tapered gradually

Benefits

• Provides long-lasting relief from nerve pain
• Maintains steady drug levels throughout the day
• Reduces frequency of dosing compared to immediate-release forms
• Helps improve sleep disturbed by chronic pain
• Supports management of fibromyalgia and anxiety symptoms

Side Effects

Common side effects may include:

• Dizziness
• Drowsiness
• Dry mouth
• Blurred vision
• Weight gain
• Swelling in hands or feet

Serious side effects may include:

• Mood changes or depression
• Severe allergic reactions
• Suicidal thoughts (rare but important to monitor)

Seek medical attention if severe symptoms occur.

Precautions and Warnings

• May cause dizziness and drowsiness; avoid driving if affected
• Use cautiously in patients with kidney impairment
• Avoid alcohol as it may increase sedation
• Do not stop abruptly without medical supervision
• Monitor for mood or behavioral changes
• Use during pregnancy or breastfeeding only if prescribed

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Pregan ER Tablet may interact with:

• CNS depressants (alcohol, sedatives)
• Opioid analgesics
• Anti-anxiety medications

Always inform your healthcare provider about all medicines being used.

Storage

• Store below 30°C in a cool and dry place
• Protect from light and moisture
• Keep out of reach of children.