Progut-N Tablet is a combination medicine containing Naproxen Sodium, a non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole Magnesium, a proton pump inhibitor (PPI). It is designed to provide effective relief from pain and inflammation while protecting the stomach from NSAID-induced gastric irritation. This combination is commonly used in musculoskeletal and inflammatory conditions requiring long-term pain management with gastric safety.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Naproxen Sodium 500 mg
• Esomeprazole Magnesium 20 mg

Indications

Progut-N Tablet is indicated for:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Acute musculoskeletal pain
• Back pain and joint pain
• Inflammatory conditions requiring NSAID therapy
• Pain management with gastric protection requirement

Mechanism of Action

• Naproxen Sodium inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis, which helps decrease pain, swelling, and inflammation.
• Esomeprazole Magnesium suppresses gastric acid secretion by inhibiting the proton pump in gastric parietal cells, reducing the risk of NSAID-induced gastric ulcers and irritation.

Together, they provide strong anti-inflammatory action with gastrointestinal protection.

Dosage and Administration

• Usually taken once daily or as directed by a physician.
• Swallow whole with water, preferably before meals.
• Do not crush or chew the tablet.
• Dosage depends on severity of condition and patient response.
• Use the lowest effective dose for the shortest duration necessary.

Benefits

• Powerful relief from pain and inflammation
• Reduces risk of NSAID-induced gastric ulcers
• Improves mobility in joint and muscle disorders
• Convenient single-tablet combination therapy
• Suitable for chronic inflammatory conditions under supervision

Side Effects

Progut-N Tablet may cause:

• Abdominal pain or discomfort
• Nausea or vomiting
• Headache
• Dizziness
• Gastric irritation (reduced due to PPI component)
• Increased risk of bleeding (rare)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with kidney, liver, or heart disease.
• Long-term use should be under medical supervision.
• May increase risk of cardiovascular events with prolonged NSAID use.
• Avoid in active peptic ulcer or gastrointestinal bleeding.
• Inform physician about all concurrent medications.

Storage

• Store below 30°C
• Protect from moisture and light
• Keep out of reach of children.