Proston Vaginal Gel 0.5 mg/3 gm contains Dinoprostone, a naturally occurring prostaglandin (PGE2) used to induce cervical ripening and facilitate labor in pregnant women. This topical vaginal gel provides a controlled and effective method for preparing the cervix, making it a trusted option in obstetric care for women requiring induction of labor.

Dinoprostone acts locally on the cervical tissue, softening and dilating the cervix while stimulating uterine contractions. The gel formulation allows for precise dosing and gradual absorption, ensuring predictable clinical effects and minimizing systemic exposure. Proston Vaginal Gel is commonly used in hospital settings under medical supervision to promote safe and efficient labor induction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Proston Vaginal Gel 0.5 mg/3 gm is indicated for:

• Cervical ripening in term or near-term pregnancies when labor induction is medically indicated.

• Induction of labor in women with a favorable or unfavorable cervix.

• Management of missed or incomplete abortion, where cervical preparation is required for safe uterine evacuation.

This gel is recommended when non-invasive cervical preparation is preferred, or when oral or intravenous alternatives are less suitable.

Dosage and Administration

• Administration: Proston Gel is inserted into the vagina near the cervical canal using a prefilled applicator.

• Dose: Each 3 gm applicator contains 0.5 mg of Dinoprostone. The exact dosing schedule and frequency depend on the patient’s clinical status and cervical readiness.

• Continuous monitoring of maternal and fetal condition is required during and after administration.

• Do not exceed the recommended dose, as excessive use may increase the risk of uterine hyperstimulation or fetal distress.

The gel should be used exclusively under obstetric supervision in a hospital or clinical setting to ensure maternal and fetal safety.

Mechanism of Action

Dinoprostone in Proston Gel acts as a prostaglandin E2 analog:

• It softens the cervical tissue by breaking down collagen fibers and increasing water content.

• Stimulates uterine contractions to facilitate labor.

• Prepares the cervix for dilation and delivery, reducing the need for mechanical induction methods.

By mimicking natural prostaglandin activity, Proston Gel provides safe, physiological cervical ripening.

Precautions

• Use only under medical supervision in a hospital setting.

• Monitor maternal vital signs and fetal heart rate continuously.

• Avoid use in cases of uterine scarring, cephalopelvic disproportion, placenta previa, or active vaginal bleeding.

• Inform the healthcare provider about any allergies or medical conditions prior to use.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Proston Gel is generally well-tolerated. Possible side effects include:

• Uterine hyperstimulation, cramping, or mild abdominal pain

• Nausea, vomiting, or diarrhea

• Rarely, fetal distress or uterine rupture in predisposed patients

Most adverse effects are manageable with close medical supervision.

Storage

Store Proston Vaginal Gel 0.5 mg/3 gm at 2°C–8°C, protected from light and moisture. Keep out of reach of children.

Proston Vaginal Gel offers a safe and effective method for cervical ripening and labor induction, helping obstetricians facilitate delivery while minimizing risks for both mother and child.