Relentus 2 mg Tablet contains Tizanidine, a centrally acting skeletal muscle relaxant used for the management of painful muscle spasms and spasticity due to neurological disorders. It is particularly effective for conditions associated with spinal disorders, post-surgical recovery, or neurological diseases such as multiple sclerosis, cerebral palsy, chronic myelopathy, degenerative spinal cord disease, and cerebrovascular accidents. By targeting the central nervous system, Relentus helps reduce muscle tone, alleviate spasms, and improve mobility, while also exerting moderate analgesic effects.

Tizanidine is designed for individualized dosing due to its narrow therapeutic index and variable plasma levels. It is available in tablet form and is suitable for adults, including elderly patients with appropriate dose adjustments.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Centrally Acting Skeletal Muscle Relaxant

Indications

Relentus 2 mg is indicated for:

• Relief of Painful Muscle Spasms:
  Associated with static and functional disorders of the spine, including cervical and lumbar syndromes, and post-surgical recovery such as after herniated disc surgery or hip osteoarthritis.

• Spasticity Due to Neurological Disorders:
  Conditions like multiple sclerosis, chronic myelopathy, degenerative spinal cord diseases, cerebral palsy, and cerebrovascular accidents.

Pharmacology

Tizanidine is a short-acting α2-adrenergic agonist that acts primarily at the spinal cord. It increases presynaptic inhibition of motor neurons, reducing excitatory neurotransmitter release and limiting polysynaptic reflexes. Unlike direct-acting muscle relaxants, tizanidine does not act on skeletal muscle fibers or neuromuscular junctions. Its antispastic effects are most pronounced on polysynaptic pathways, resulting in reduced muscle tone, decreased spasms, and improved voluntary movement. Additionally, tizanidine has moderate central analgesic properties, providing pain relief alongside muscle relaxation.

Mode of Action

• Stimulates presynaptic α2 receptors in the spinal cord to inhibit excitatory amino acid release

• Reduces polysynaptic signal transmission responsible for excessive muscle tone

• Decreases spasticity, muscle resistance, and clonus while moderately relieving pain

Dosage and Administration

• Initial Dose: 2 mg once daily

• Titration: Increase in 2 mg increments every 3–4 days as needed, up to 24 mg daily in 3–4 divided doses

• Maximum Dose: 36 mg daily

• For Painful Muscle Spasms: 2–4 mg three times daily; additional nighttime doses may be given for severe cases

• For Neurological Spasticity: Start with ≤6 mg/day divided into 3 doses; optimum response usually achieved at 12–24 mg/day

• Special Populations:

  • Elderly: Start at lowest dose, titrate carefully

  • Renal Impairment: Start at 2 mg once daily, increase cautiously

  • Hepatic Impairment: Contraindicated in severe cases; use caution in moderate impairment

Discontinuation should be gradual to avoid rebound hypertension and tachycardia.

Drug Interactions

• CYP1A2 inhibitors (fluvoxamine, ciprofloxacin): Contraindicated due to risk of severe hypotension and prolonged tizanidine levels

• Other CYP1A2 inhibitors: Use with caution (e.g., amiodarone, cimetidine)

• Drugs prolonging QT interval: Caution advised

• Antihypertensives: May enhance hypotensive effects

• Alcohol, sedatives, hypnotics: May potentiate CNS depressant effects

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to tizanidine

• Severe hepatic impairment

• Concomitant use with strong CYP1A2 inhibitors

Side Effects

• Very common: somnolence, dizziness, fatigue, muscle weakness, gastrointestinal disorders

• Common: hypotension, bradycardia, nausea, dry mouth, increased liver enzymes

• Rare: hallucinations, sleep disorders, hepatitis, hypersensitivity reactions

Pregnancy and Lactation

• Limited human data; use only if benefit outweighs risk

• Animal studies: No teratogenic effects but possible fetal growth and developmental effects at high doses

• Not recommended during breastfeeding

Precautions and Warnings

• Monitor liver function monthly for high doses

• Avoid abrupt discontinuation to prevent rebound hypertension

• Patients experiencing sedation or hypotension should avoid driving or operating machinery

• Use caution in elderly and renally impaired patients

Overdose

Symptoms: hypotension, bradycardia, somnolence, respiratory depression, QT prolongation, coma
Management: activated charcoal, supportive care, and forced diuresis

Storage Conditions

Store in a dry place below 30°C, away from light and moisture.
Keep out of reach of children.