Ribox 90 mg Tablet is a selective cyclooxygenase-2 (COX-2) inhibitor belonging to the non-steroidal anti-inflammatory drug (NSAID) class. It is specifically formulated to provide effective relief from pain and inflammation while minimizing gastrointestinal side effects commonly associated with non-selective NSAIDs. Ribox 90 mg is suitable for managing chronic inflammatory conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute episodes of gouty arthritis, as well as short-term moderate pain following dental surgery.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Ribox 90 mg is indicated for:

• Symptomatic relief in Osteoarthritis (OA)

• Management of Rheumatoid Arthritis (RA)

• Treatment of Ankylosing Spondylitis

• Relief of pain and inflammation in acute gouty arthritis

• Short-term management of moderate pain following dental surgery

Therapeutic Class

Non-steroidal anti-inflammatory drug (NSAID) – COX-2 selective

Pharmacology

Ribox 90 mg works by selectively inhibiting COX-2, the enzyme responsible for producing prostaglandins that mediate pain, inflammation, and fever. Unlike non-selective NSAIDs, it minimally affects COX-1, which maintains gastric mucosa and platelet function. This selective inhibition allows Ribox 90 mg to:

• Reduce inflammation and swelling in joints and tissues

• Relieve pain associated with arthritis, gout, and postoperative conditions

• Minimize gastrointestinal toxicity and the risk of bleeding compared to traditional NSAIDs

Dosage and Administration

Adults and adolescents over 16 years:

• Osteoarthritis: 30–60 mg once daily

• Rheumatoid Arthritis: 90 mg once daily

• Ankylosing Spondylitis: 90 mg once daily

• Acute Gouty Arthritis: 120 mg once daily for up to 8 days

• Postoperative dental pain: 90 mg once daily, limited to 3 days

Administration Guidelines:

• Take with or without food.

• Use the lowest effective dose for the shortest duration to reduce cardiovascular and gastrointestinal risks.

• Regularly re-evaluate patient response and symptom control.

Drug Interactions

• Oral anticoagulants (warfarin): May increase prothrombin time.

• ACE inhibitors, angiotensin II antagonists, diuretics: NSAIDs may reduce antihypertensive efficacy.

• Lithium: Risk of increased plasma levels.

• Cyclosporin or tacrolimus: May increase nephrotoxicity.

• Can be used with low-dose aspirin for cardiovascular protection.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Ribox or other NSAIDs

• Active peptic ulcer or gastrointestinal bleeding

• Severe hepatic or renal impairment

• Congestive heart failure, uncontrolled hypertension, ischemic heart disease

• Children under 16 years

• Pregnancy and lactation

Side Effects

Common side effects include:

• Fatigue, palpitations, influenza-like symptoms

• Gastrointestinal disturbances: dyspepsia, nausea

• Rare: atrial fibrillation, chest pain, flushing, electrolyte disturbances, confusion, hallucinations

Precautions and Warnings

• Monitor renal and hepatic function during prolonged therapy

• Caution in patients at high gastrointestinal or cardiovascular risk

• Discontinue immediately if rash, mucosal lesions, or hypersensitivity occurs

• May mask fever and other signs of inflammation

Pregnancy and Lactation

• Avoid during pregnancy, especially in late stages, due to risk of premature ductus arteriosus closure

• Not recommended during breastfeeding as excretion in human milk is unknown

Storage Conditions

Store below 30°C in a dry, dark place, away from moisture and out of reach of children.

Mode of Action

Ribox 90 mg selectively inhibits COX-2, reducing prostaglandin synthesis responsible for pain, inflammation, and fever. Minimal COX-1 inhibition preserves gastric mucosal protection and platelet function. This selectivity provides effective anti-inflammatory and analgesic effects while lowering the risk of gastrointestinal adverse events compared to traditional NSAIDs.