Rostab EZ Tablet 20 mg+10 mg is a high-potency combination tablet containing Rosuvastatin Calcium 20 mg and Ezetimibe 10 mg, specifically formulated for adults who require intensive lipid-lowering therapy. This combination is ideal for patients with primary hypercholesterolemia, mixed dyslipidemia, or familial hypercholesterolemia, particularly those who have not achieved target cholesterol levels with monotherapy.

Rosuvastatin, a potent HMG-CoA reductase inhibitor, reduces cholesterol synthesis in the liver, while Ezetimibe selectively blocks intestinal absorption of cholesterol. The synergistic effect of these two agents produces significant reduction in low-density lipoprotein (LDL) cholesterol, total cholesterol, and triglycerides, while modestly increasing high-density lipoprotein (HDL) cholesterol. By targeting cholesterol production and absorption simultaneously, Rostab EZ 20 mg+10 mg offers maximized efficacy and cardiovascular protection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Rosuvastatin Calcium 20 mg

• Ezetimibe 10 mg

• Excipients: Microcrystalline cellulose, lactose, magnesium stearate, and other standard tablet excipients

Indications

Rostab EZ Tablet 20 mg+10 mg is indicated for:

• Primary hypercholesterolemia to lower LDL and total cholesterol

• Mixed dyslipidemia with elevated LDL and triglycerides

• Familial hypercholesterolemia as an adjunct to diet and lifestyle modification

• Adults requiring intensive lipid-lowering therapy when monotherapy is insufficient

• Prevention of cardiovascular events, including myocardial infarction, stroke, and angina, in high-risk patients

Mechanism of Action

Rostab EZ combines two complementary mechanisms to manage lipid levels effectively:

1. Rosuvastatin Calcium:

   • Inhibits HMG-CoA reductase, a key enzyme in hepatic cholesterol synthesis

   • Reduces LDL cholesterol and triglycerides, while slightly increasing HDL cholesterol

   • Stabilizes atherosclerotic plaques and improves endothelial function

2. Ezetimibe:

   • Blocks cholesterol absorption at the intestinal brush border

   • Reduces cholesterol delivery to the liver

   • Enhances LDL-lowering effects when combined with Rosuvastatin

The combination provides greater cholesterol-lowering efficacy than either agent alone, making it suitable for patients with high cardiovascular risk or refractory hyperlipidemia.

Dosage and Administration

• Adults: 1 tablet once daily, with or without food

• Preferably taken in the evening, when hepatic cholesterol synthesis is highest

• Continue dietary modifications, regular exercise, and weight management alongside medication

• Regular monitoring of lipid profile, liver function, and kidney function is recommended

• Dose adjustments may be made by the physician based on response and tolerability

Precautions and Warnings

• Avoid use in patients with active liver disease or unexplained persistent liver enzyme elevations

• Use cautiously in patients with renal impairment or history of muscle disorders

• Inform your physician about all medications being taken to prevent interactions, especially with CYP3A4 inhibitors

• Not recommended during pregnancy or breastfeeding

• Seek immediate medical attention for unexplained muscle pain, tenderness, or weakness, which may indicate rhabdomyolysis

Possible Side Effects

Rostab EZ Tablet 20 mg+10 mg is generally well tolerated. Common side effects may include:

• Headache

• Gastrointestinal discomfort (nausea, abdominal pain)

• Muscle pain, stiffness, or weakness

• Temporary elevation of liver enzymes

• Rarely, serious muscle injury (rhabdomyolysis)

Most adverse effects are mild, transient, and manageable with dose adjustment or discontinuation under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store below 30°C in a cool, dry place

• Protect from light and moisture

• Keep out of reach of children

Conclusion

Rostab EZ Tablet 20 mg+10 mg (Rosuvastatin + Ezetimibe) is a high-potency combination therapy for adults who need intensive cholesterol management. By targeting both cholesterol synthesis and absorption, it effectively lowers LDL cholesterol, reduces triglycerides, and improves overall lipid profile. When used alongside lifestyle modifications, Rostab EZ supports cardiovascular risk reduction and long-term heart health.