Salflu Inhaler (25 mcg+125 mcg per puff) is a combination metered-dose inhaler containing Salmeterol 25 mcg, a long-acting beta-2 adrenergic agonist (LABA), and Fluticasone Propionate 125 mcg, an inhaled corticosteroid (ICS). This formulation is specifically designed for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD), providing dual-action therapy that addresses both bronchoconstriction and airway inflammation.

Salmeterol relaxes the smooth muscles in the airways, allowing easier airflow and prevention of bronchospasm, while Fluticasone Propionate reduces airway inflammation, swelling, and mucus production, preventing exacerbations. This combination ensures better symptom control, improved lung function, and enhanced quality of life for patients with persistent respiratory conditions. The inhaler delivers a precise dose with every puff, ensuring consistent therapy and convenient administration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each actuation (puff) contains:

• Salmeterol 25 mcg

• Fluticasone Propionate 125 mcg

• Propellants and excipients to ensure uniform delivery via a metered-dose inhaler

Indications

Salflu Inhaler 25/125 mcg is indicated for:

• Maintenance treatment of asthma in adults and adolescents

• Long-term management of COPD to improve airflow and reduce symptom frequency

• Prevention of exercise-induced bronchospasm when used as maintenance therapy

• Patients not adequately controlled with monotherapy ICS

• Reduction of asthma exacerbations and improvement of overall respiratory health

Mechanism of Action

The therapeutic effect of Salflu Inhaler is based on the complementary action of its two active ingredients:

1. Salmeterol (LABA):

   • Stimulates beta-2 adrenergic receptors in bronchial smooth muscles

   • Causes prolonged bronchodilation, easing breathing and reducing wheezing, cough, and chest tightness

   • Duration of action is approximately 12 hours, supporting twice-daily dosing

2. Fluticasone Propionate (ICS):

   • Suppresses airway inflammation by inhibiting inflammatory cells and mediators

   • Reduces airway edema, mucus secretion, and hyperresponsiveness

   • Prevents airway remodeling, decreases asthma attacks, and improves long-term lung function

Together, these actions ensure controlled airflow, reduced inflammation, and fewer respiratory exacerbations.

Dosage and Administration

• Adults and adolescents: 1–2 puffs twice daily, or as prescribed by a physician

• Shake the inhaler well before each use

• Breathe out fully, place the mouthpiece in the mouth, inhale deeply while pressing the canister, and hold the breath for 5–10 seconds

• Rinse mouth with water after inhalation to prevent oral thrush

• Not intended for rescue treatment of acute asthma attacks; use a short-acting bronchodilator for emergencies

Precautions and Warnings

• Not suitable for acute bronchospasm or sudden asthma attacks

• Use cautiously in patients with cardiovascular disease, hypertension, diabetes, or thyroid disorders

• Avoid abrupt discontinuation to prevent adrenal insufficiency

• Monitor for paradoxical bronchospasm, worsening symptoms, or allergic reactions

• Pediatric, elderly, or pregnant patients should use under strict medical supervision

Possible Side Effects

Salflu Inhaler 25/125 mcg is generally well tolerated. Common side effects include:

• Throat irritation, hoarseness, or cough

• Oral candidiasis (thrush)

• Headache or mild dizziness

• Tremors or palpitations (rare, due to Salmeterol)

• Rare systemic corticosteroid effects, such as adrenal suppression

Most side effects are mild and can be minimized with correct inhalation technique and mouth rinsing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a cool, dry place below 30°C

• Protect from light, heat, and moisture

• Keep out of reach of children

• Do not puncture or expose the inhaler to fire

Conclusion

Salflu Inhaler (25 mcg+125 mcg per puff) provides effective maintenance therapy for asthma and COPD by combining bronchodilation with anti-inflammatory action. Regular use ensures improved airflow, reduced symptoms, and prevention of exacerbations, supporting better respiratory health and quality of life. Proper inhaler technique and adherence to physician guidance are essential for optimal outcomes.