Salflu Inhaler (25 mcg+250 mcg per puff) is a combination metered-dose inhaler containing Salmeterol 25 mcg, a long-acting beta-2 adrenergic agonist (LABA), and Fluticasone Propionate 250 mcg, an inhaled corticosteroid (ICS). This inhaler is specifically formulated for the maintenance treatment of moderate to severe asthma and chronic obstructive pulmonary disease (COPD), offering dual-action therapy that addresses both bronchoconstriction and airway inflammation.

Salmeterol provides prolonged bronchodilation, relaxing the smooth muscles of the airways, while Fluticasone Propionate reduces airway inflammation, edema, and mucus secretion, preventing exacerbations and improving lung function. The inhaler delivers a precise dose with each puff, ensuring consistent and effective therapy. Salflu 25/250 mcg is ideal for patients whose symptoms are not adequately controlled with low-dose ICS or ICS/LABA combinations, offering enhanced symptom control and improved quality of life.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each actuation (puff) contains:

• Salmeterol 25 mcg

• Fluticasone Propionate 250 mcg

• Propellants and excipients to stabilize the formulation and ensure accurate delivery via a metered-dose inhaler (MDI)

Indications

Salflu Inhaler 25/250 mcg is indicated for:

• Maintenance therapy for moderate to severe asthma in adults and adolescents

• Long-term management of COPD to improve lung function and reduce symptoms

• Prevention of exercise-induced bronchospasm when used as part of maintenance therapy

• Patients inadequately controlled on low-dose ICS or ICS/LABA combinations

• Reduction of asthma exacerbations and improvement of overall respiratory health

Mechanism of Action

The combination of Salmeterol and Fluticasone Propionate provides complementary therapeutic effects:

1. Salmeterol (Long-acting beta-2 agonist):

   • Stimulates beta-2 adrenergic receptors in the bronchial smooth muscles

   • Produces long-lasting bronchodilation, easing breathing and reducing wheezing, chest tightness, and shortness of breath

   • Duration of action is approximately 12 hours, supporting twice-daily dosing

2. Fluticasone Propionate (Inhaled corticosteroid):

   • Reduces airway inflammation by suppressing inflammatory cells and mediators

   • Minimizes airway edema, mucus secretion, and hyperresponsiveness

   • Prevents airway remodeling and decreases frequency of asthma attacks

Together, these actions provide controlled airflow, reduced inflammation, and prevention of respiratory exacerbations, ensuring better lung function and symptom control.

Dosage and Administration

• Adults and adolescents: 1–2 puffs twice daily, or as prescribed by the physician

• Shake the inhaler well before each use

• Exhale fully, place the mouthpiece in the mouth, inhale deeply while pressing the canister, and hold the breath for 5–10 seconds

• Rinse mouth after inhalation to prevent oral thrush and irritation

• Not a rescue inhaler; use a short-acting bronchodilator for sudden asthma attacks

Precautions and Warnings

• Not for acute bronchospasm or sudden asthma attacks

• Use cautiously in patients with cardiovascular disease, hypertension, diabetes, or thyroid disorders

• Avoid abrupt discontinuation to prevent adrenal insufficiency

• Report paradoxical bronchospasm, worsening symptoms, or allergic reactions immediately

• Pediatric, elderly, or pregnant patients should use under strict medical supervision

Possible Side Effects

Salflu Inhaler 25/250 mcg is generally well tolerated. Common side effects include:

• Throat irritation or hoarseness

• Oral candidiasis (thrush)

• Headache or mild dizziness

• Tremors or palpitations (rare, due to Salmeterol)

• Rare systemic corticosteroid effects, including adrenal suppression

Most side effects are mild and preventable with proper inhalation technique and mouth rinsing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a cool, dry place below 30°C

• Protect from light, heat, and moisture

• Keep out of reach of children

• Do not puncture or expose the inhaler to fire

Conclusion

Salflu Inhaler (25 mcg+250 mcg per puff) provides effective maintenance therapy for moderate to severe asthma and COPD. Its combination of bronchodilation and anti-inflammatory action improves airflow, prevents exacerbations, and enhances overall respiratory health. Regular use with proper inhaler technique and physician guidance ensures optimal symptom control and long-term lung function improvement.