Salpium Inhaler (100 mcg+20 mcg per puff) is a combination metered-dose inhaler (MDI) containing Salbutamol 100 mcg and Ipratropium Bromide 20 mcg per actuation. This dual-action inhaler is formulated for the management and relief of bronchospasm in patients with asthma, chronic obstructive pulmonary disease (COPD), and other obstructive airway diseases.

Salbutamol is a fast-acting beta-2 adrenergic agonist, which relaxes bronchial smooth muscles, providing rapid bronchodilation. Ipratropium Bromide, an anticholinergic agent, blocks muscarinic receptors in the airways, reducing bronchoconstriction and mucus secretion. The combination ensures enhanced bronchodilation, faster symptom relief, and prolonged duration of action, making it especially suitable for patients with moderate to severe airway obstruction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each puff of Salpium Inhaler contains:

• Salbutamol 100 mcg

• Ipratropium Bromide 20 mcg

• Propellants and excipients to ensure stability, precise delivery, and consistent dosing

Indications

Salpium Inhaler 100/20 mcg is indicated for:

• Acute relief and maintenance therapy of bronchospasm in asthma and COPD

• Management of wheezing, chest tightness, and shortness of breath

• Adjunct therapy for patients inadequately controlled on single bronchodilator therapy

• Suitable for adults and children above 12 years

• Prevention of exercise-induced bronchospasm when used as maintenance therapy

Mechanism of Action

The therapeutic effect of Salpium Inhaler arises from the synergistic action of its two components:

1. Salbutamol (Beta-2 agonist):

   • Activates beta-2 adrenergic receptors in bronchial smooth muscles

   • Causes rapid relaxation of airways, improving airflow

   • Provides symptom relief within 5–15 minutes, lasting 4–6 hours

2. Ipratropium Bromide (Anticholinergic):

   • Blocks muscarinic receptors (M3) in the airways

   • Reduces bronchoconstriction and mucus secretion

   • Has a slower onset than Salbutamol but prolongs bronchodilation, enhancing overall efficacy

Together, they provide improved airway patency, reduced hypersecretion, and enhanced control of bronchospasm, making it a preferred option for patients with combined airway obstruction.

Dosage and Administration

• Adults and children above 12 years: 1–2 puffs every 4–6 hours as needed, or as prescribed

• Shake the inhaler well before each use

• Exhale fully, place the mouthpiece in the mouth, inhale deeply while pressing the canister, and hold the breath for 5–10 seconds

• Rinse the mouth after use to reduce throat irritation

• Not intended for continuous overuse; always follow the prescribed dosage

Precautions and Warnings

• Avoid use in patients with allergy to Salbutamol, Ipratropium, or excipients

• Use cautiously in cardiovascular disorders, hypertension, glaucoma, or urinary retention

• Monitor for paradoxical bronchospasm, worsening symptoms, or allergic reactions

• Not a substitute for long-term asthma or COPD management; use as part of a comprehensive treatment plan

• Pregnant or breastfeeding women should use under medical supervision

Possible Side Effects

Salpium Inhaler is generally well tolerated. Side effects may include:

• Tremors or shaking

• Mild palpitations or rapid heartbeat

• Dry mouth, throat irritation, or cough

• Headache or dizziness

• Rare allergic reactions

Most side effects are mild, transient, and dose-dependent, and proper inhaler technique can reduce occurrence.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a cool, dry place below 30°C

• Protect from light, heat, and moisture

• Keep out of reach of children

• Do not puncture or expose the inhaler to fire

Conclusion

Salpium Inhaler (100 mcg+20 mcg per puff) provides fast, effective, and sustained relief from bronchospasm by combining the rapid bronchodilation of Salbutamol with the anticholinergic action of Ipratropium. It is ideal for patients with asthma, COPD, or mixed airway obstruction, offering improved airflow, reduced mucus secretion, and enhanced control of respiratory symptoms. When used properly under medical guidance, it ensures safe, reliable, and convenient management of airway obstruction.