Salpium Respirator Solution (2.5 mg + 500 mcg per 3 ml) is a nebulizer solution combining Salbutamol and Ipratropium Bromide for inhalation therapy. This combination provides rapid and sustained relief from bronchospasm, making it ideal for patients with asthma, chronic obstructive pulmonary disease (COPD), and other obstructive airway diseases.

Salbutamol is a fast-acting beta-2 adrenergic receptor agonist, which relaxes bronchial smooth muscles and delivers quick bronchodilation. Ipratropium Bromide is an anticholinergic agent that blocks muscarinic receptors in the airways, reducing bronchoconstriction and mucus production. Together, these agents provide enhanced bronchodilation, symptom control, and improved respiratory function, especially in patients with moderate to severe airway obstruction.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 3 ml of Salpium Respirator Solution contains:

• Salbutamol 2.5 mg

• Ipratropium Bromide 500 mcg

• Inactive ingredients including sterile water, stabilizers, and preservatives to ensure stability, safety, and effective nebulization

Indications

Salpium Respirator Solution is indicated for:

• Relief of acute bronchospasm in asthma and COPD

• Management of wheezing, shortness of breath, and chest tightness

• Adjunct therapy for patients inadequately controlled on single bronchodilator therapy

• Prevention and treatment of exercise-induced bronchospasm

• Suitable for adults, elderly patients, and children under medical supervision

Mechanism of Action

The solution provides dual bronchodilator action through:

1. Salbutamol (Beta-2 agonist):

   • Stimulates beta-2 receptors in bronchial smooth muscle

   • Causes rapid relaxation of the airways, relieving bronchospasm

   • Onset of action occurs within 5–15 minutes, lasting 4–6 hours

2. Ipratropium Bromide (Anticholinergic):

   • Blocks muscarinic M3 receptors in the airway

   • Reduces bronchoconstriction and excessive mucus secretion

   • Provides prolonged bronchodilation and complements Salbutamol for sustained effect

The combination ensures synergistic bronchodilation, better symptom control, and improved airflow, making it highly effective for patients with mixed or severe airway obstruction.

Dosage and Administration

• Adults and children over 12 years: 3 ml via nebulizer every 6–8 hours, or as prescribed

• Children under 12 years: Dose should be adjusted by a physician based on age and severity

• Administer using a standard nebulizer device

• Breathe normally during nebulization for 5–15 minutes until the medication is fully inhaled

• Do not exceed prescribed frequency to avoid side effects

Precautions and Warnings

• Use with caution in patients with heart disease, hypertension, glaucoma, urinary retention, or diabetes

• Avoid overuse, which may lead to tachycardia, tremors, or nervousness

• Monitor for paradoxical bronchospasm, worsening symptoms, or allergic reactions

• Not intended as a replacement for long-term asthma or COPD therapy; use as part of a comprehensive treatment plan

• Pregnant or breastfeeding women should use under medical supervision

Possible Side Effects

Salpium Respirator Solution is generally well tolerated. Side effects may include:

• Tremors or hand shaking

• Rapid heartbeat (tachycardia)

• Dry mouth, throat irritation, or mild cough

• Headache or dizziness

• Rare allergic reactions

Most side effects are mild, transient, and dose-dependent. Proper nebulization technique can minimize discomfort.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a cool, dry place below 30°C

• Protect from light and contamination

• Keep out of reach of children

• Use each vial for a single nebulization session and discard any remaining solution

Conclusion

Salpium Respirator Solution (2.5 mg + 500 mcg per 3 ml) provides rapid and sustained relief from bronchospasm through the synergistic effects of Salbutamol and Ipratropium. It is ideal for patients with asthma, COPD, or mixed airway obstruction, offering improved airflow, reduced mucus production, and enhanced symptom control. When used under medical supervision, it ensures safe, reliable, and effective management of acute and chronic respiratory conditions.