Savesto Tablet 49 mg + 51 mg contains Sacubitril and Valsartan, a combination medicine used in the management of chronic heart failure. It works by improving heart function, reducing strain on the heart, and lowering the risk of hospitalization and cardiovascular death in patients with reduced ejection fraction heart failure.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Sacubitril 49 mg
• Valsartan 51 mg

Indications

Savesto Tablet is indicated for:

• Chronic heart failure with reduced ejection fraction (HFrEF)
• Reduction of risk of cardiovascular death and hospitalization in heart failure patients
• Management of symptomatic heart failure in clinically stable patients

Mechanism of Action

This combination works through dual pathways:

• Sacubitril inhibits neprilysin, increasing levels of beneficial natriuretic peptides that promote vasodilation, sodium excretion, and reduced cardiac stress
• Valsartan blocks angiotensin II receptors (ARB), reducing vasoconstriction, blood pressure, and fluid retention

Together, they improve cardiac efficiency and reduce heart workload.

Dosage and Administration

• The usual dose is one tablet twice daily or as prescribed by a physician
• Should be taken at the same time each day
• Can be taken with or without food
• Dose adjustment may be required based on blood pressure and kidney function
• Do not stop or change dosage without medical advice

Benefits

• Improves survival in heart failure patients
• Reduces hospital admissions due to heart failure
• Enhances heart pumping efficiency
• Lowers blood pressure and cardiac stress
• Improves quality of life in chronic heart failure

Possible Side Effects

Common side effects may include:

• Low blood pressure (hypotension)
• Dizziness
• Elevated potassium levels
• Cough
• Fatigue

Serious side effects:

• Angioedema (swelling of face, lips, or throat)
• Severe kidney dysfunction
• Irregular heartbeat due to high potassium

Immediate medical attention is required if severe reactions occur.

Precautions and Warnings

• Not recommended during pregnancy (risk of fetal harm)
• Use with caution in patients with kidney or liver impairment
• Monitor blood pressure, kidney function, and potassium levels regularly
• Avoid concurrent use with ACE inhibitors (must allow proper washout period)
• May cause dizziness; avoid driving if affected

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Savesto Tablet may interact with:

• ACE inhibitors
• Potassium supplements or potassium-sparing diuretics
• NSAIDs (e.g., ibuprofen)
• Other antihypertensive medicines

Always inform your doctor about all medications you are taking.

Storage

• Store below 30°C in a dry place
• Protect from moisture and light
• Keep out of reach of children.