Sefril Capsule 250 mg is an oral antibiotic formulation containing Cephradine, a first-generation cephalosporin used to treat a variety of bacterial infections. It is effective against both Gram-positive and select Gram-negative bacteria, providing a broad spectrum of antimicrobial activity.

Cephradine works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. It is commonly prescribed for respiratory tract infections, skin and soft tissue infections, urinary tract infections, and otitis media, among other bacterial infections. Sefril Capsule 250 mg is ideal for adults and children above a certain age, offering effective and convenient oral therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each capsule contains:

• Cephradine 250 mg

• Inactive ingredients for capsule stability and bioavailability

Indications

Sefril Capsule 250 mg is indicated for the treatment of infections caused by susceptible bacteria, including:

• Respiratory tract infections: pharyngitis, tonsillitis, bronchitis, and pneumonia

• Skin and soft tissue infections: cellulitis, abscesses, and wound infections

• Urinary tract infections: cystitis and pyelonephritis

• Ear infections: otitis media

• Bone and joint infections caused by susceptible organisms

• Prophylaxis in certain surgical procedures where risk of infection is high

Mechanism of Action

Cephradine is a beta-lactam antibiotic that works by:

• Binding to penicillin-binding proteins (PBPs) in bacterial cell walls

• Inhibiting the final stage of cell wall synthesis, leading to bacterial lysis

• Causing bactericidal action against actively dividing bacteria

• Effective primarily against Gram-positive bacteria such as Staphylococcus aureus and Streptococcus species, and selected Gram-negative organisms like E. coli and Klebsiella species

Its oral administration ensures rapid absorption and systemic distribution, making it convenient for outpatient treatment of infections.

Dosage and Administration

• Adults: 250–500 mg orally every 6–12 hours, depending on infection severity

• Children: Dose calculated based on body weight, usually 25–50 mg/kg/day divided into 3–4 doses

• Capsules should be taken with a full glass of water, preferably on an empty stomach for better absorption

• Complete the full course even if symptoms improve early to prevent recurrence and resistance

Precautions and Warnings

• Use cautiously in patients with history of penicillin allergy or hypersensitivity to cephalosporins

• Adjust dosage in patients with impaired renal function

• Not effective against viral infections; unnecessary use may lead to resistance

• Inform your physician about pregnancy, breastfeeding, or concomitant medications before use

Possible Side Effects

Sefril Capsule 250 mg is generally well tolerated. Side effects may include:

• Gastrointestinal disturbances: nausea, vomiting, diarrhea, abdominal discomfort

• Allergic reactions: rash, itching, urticaria

• Rare reactions: anaphylaxis, neutropenia, or liver enzyme changes

Most side effects are mild and reversible upon discontinuation or adjustment of therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a cool, dry place below 25°C

• Protect from moisture and direct sunlight

• Keep out of reach of children

• Do not use capsules past their expiry date

Conclusion

Sefril Capsule 250 mg (Cephradine) is a reliable first-generation cephalosporin for treating a wide range of bacterial infections. Its broad-spectrum activity, oral convenience, and proven safety profile make it suitable for adults and children. When used according to medical guidance, it provides effective bacterial eradication, symptom relief, and prevention of infection complications.