Sliptin-M ER Tablet 50 mg + 500 mg is a combination oral anti-diabetic medicine containing Sitagliptin 50 mg and Metformin Hydrochloride 500 mg (Extended Release). It is prescribed for the management of type 2 diabetes mellitus in adults, especially when blood sugar levels are not adequately controlled by diet, exercise, or single-drug therapy. The extended-release (ER) formulation of metformin allows for gradual release of the medicine, improving tolerability and providing sustained blood glucose control throughout the day.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition and Mechanism of Action

Sitagliptin is a DPP-4 (dipeptidyl peptidase-4) inhibitor. It works by increasing incretin hormone levels in the body. These hormones stimulate the pancreas to release insulin in response to meals and reduce the amount of glucose produced by the liver. Sitagliptin mainly lowers post-meal blood sugar levels and carries a low risk of hypoglycemia when used alone.

Metformin Hydrochloride (Extended Release) belongs to the biguanide class of anti-diabetic medicines. It decreases glucose production in the liver, reduces intestinal absorption of glucose, and improves insulin sensitivity in muscle tissues. The extended-release formulation ensures a slow and steady release of metformin, which helps minimize gastrointestinal side effects such as nausea and diarrhea.

The combination provides dual-action blood sugar control by improving insulin secretion and enhancing insulin sensitivity.

Indications

Sliptin-M ER 50 mg + 500 mg is indicated for:

• Adults with type 2 diabetes mellitus

• Patients inadequately controlled on metformin alone

• Patients already taking sitagliptin and metformin separately

• As part of combination therapy with other anti-diabetic agents when needed

It is not recommended for type 1 diabetes or diabetic ketoacidosis.

Dosage and Administration

The dosage is determined by the physician based on blood glucose levels and kidney function. It is usually taken once daily with the evening meal to reduce stomach-related side effects. The tablet should be swallowed whole and not crushed, broken, or chewed, as this may interfere with the extended-release mechanism.

Side Effects

Common side effects may include:

• Nausea

• Diarrhea

• Stomach upset

• Headache

• Nasopharyngitis

Rare but serious side effects include lactic acidosis (associated with metformin) and pancreatitis (associated with sitagliptin). Patients should seek immediate medical care if they experience severe abdominal pain, breathing difficulty, unusual tiredness, or muscle pain.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Kidney function should be assessed before and during treatment

• Avoid excessive alcohol consumption

• Not recommended in severe renal impairment

• Caution in liver disease

• Use during pregnancy or breastfeeding only under medical supervision

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.