Tetracef Injection 500 mg/vial is a bactericidal β-lactam antibiotic. Like other cephalosporins, it inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby blocking the final transpeptidation step of peptidoglycan formation. This leads to weakening of the bacterial cell wall and subsequent cell lysis.
Cefepime is highly stable against many β-lactamases and demonstrates potent activity against a wide range of Gram-negative organisms, while retaining good efficacy against Gram-positive bacteria.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Tetracef Injection is indicated for the treatment of infections caused by susceptible organisms, including:

• Moderate to severe pneumonia, including cases with concurrent bacteremia, caused by Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterobacter species

• Febrile neutropenia, for empiric monotherapy in selected patients

• Uncomplicated and complicated urinary tract infections (UTIs), including pyelonephritis

• Uncomplicated skin and skin structure infections caused by methicillin-susceptible Staphylococcus aureus and Streptococcus pyogenes

• Complicated intra-abdominal infections (used in combination with metronidazole)

Dosage and Administration

Tetracef Injection 500 mg/vial is administered intravenously or intramuscularly. IV infusion should be given over approximately 30 minutes.

Typical adult dosage (may vary depending on infection severity):

• Pneumonia: 1–2 g IV every 12 hours

• Febrile neutropenia: 2 g IV every 8 hours

• UTIs: 0.5–2 g IV/IM every 12 hours

• Skin and skin structure infections: 2 g IV every 12 hours

• Intra-abdominal infections: 2 g IV every 12 hours (with metronidazole)

Dosage adjustment is required in patients with renal impairment.

Contraindications

• Known hypersensitivity to cefepime, cephalosporins, penicillins, or other β-lactam antibiotics

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common adverse effects may include:

• Injection site reactions

• Gastrointestinal disturbances (diarrhea, nausea)

• Rash or hypersensitivity reactions

Serious but rare adverse effects include encephalopathy, seizures, myoclonus, particularly in patients with renal impairment receiving unadjusted doses.

Pregnancy and Lactation

• Pregnancy Category B: No adequate, well-controlled studies in pregnant women; use only if clearly needed

• Cefepime is excreted into breast milk in very low concentrations; caution is advised during breastfeeding

Precautions and Warnings

• Use with caution in patients with renal impairment and adjust dose accordingly

• Prolonged use may result in superinfection with non-susceptible organisms

• Monitor renal function and prothrombin time in at-risk patients

• Prescribing without a proven or suspected bacterial infection may increase antimicrobial resistance

Storage Conditions

• Do not use after the expiry date

• Store as directed and keep out of reach of children

• To be dispensed only on the prescription of a registered physician.