Veracal Injection 5 mg/2 ml contains Verapamil Hydrochloride, a potent calcium channel blocker used primarily in acute cardiovascular conditions where rapid control of heart rate or blood pressure is required. This injectable formulation is especially valuable in emergency and hospital settings for the management of specific tachyarrhythmias and hypertensive crises. By acting directly on cardiac conduction and vascular smooth muscle, Veracal Injection provides fast and effective therapeutic action.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Calcium-channel blockers

Pharmacology

Verapamil Hydrochloride inhibits the transmembrane influx of calcium ions through slow L-type calcium channels in myocardial cells and vascular smooth muscle during depolarization. Calcium is essential for myocardial contraction and electrical conduction through the atrioventricular (AV) node. By reducing calcium entry, verapamil decreases myocardial contractility, slows AV nodal conduction, and prolongs the refractory period of the AV node. In addition, it relaxes coronary and peripheral vascular smooth muscle, resulting in vasodilation and improved myocardial oxygen supply. These actions make verapamil particularly effective in the acute management of supraventricular arrhythmias and elevated blood pressure.

Indications

Veracal Injection 5 mg/2 ml is indicated for the treatment of:

• Paroxysmal supraventricular tachycardia

• Atrial fibrillation with rapid ventricular response (except in patients with Wolff-Parkinson-White syndrome)

• Atrial flutter with rapid conduction

• Tachycardias requiring rapid ventricular rate control

• Acute hypertension

• Acute coronary insufficiency

• Prophylaxis and treatment of ectopic arrhythmias, particularly ventricular extrasystoles during halothane anesthesia or in association with adrenaline administration

Dosage and Administration

Veracal Injection should be administered intravenously under strict medical supervision with continuous electrocardiographic monitoring.

Adults:
A dose of 5 mg is given slowly by intravenous injection. If required, a repeat dose may be administered after 5 to 10 minutes. For maintenance of therapeutic effect, intravenous infusion may be used at a rate of 5–10 mg per hour in appropriate infusion solutions. The average total daily dose should not exceed 100 mg.

Pediatric Use:

• Newborns: 0.75–1 mg

• Infants: 0.75–2 mg

• Children 1–5 years: 2–3 mg

• Children 6–14 years: 2.5–5 mg

The injection should be administered slowly and only until the desired effect is achieved.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Veracal Injection is contraindicated in patients with:

• Severe left ventricular dysfunction

• Hypotension or cardiogenic shock

• Sick sinus syndrome (unless a functioning pacemaker is present)

• Second- or third-degree AV block (without a pacemaker)

• Atrial fibrillation or flutter with accessory conduction pathways such as WPW syndrome

• Known hypersensitivity to verapamil

Side Effects

Verapamil Injection is generally well tolerated when used appropriately. Possible side effects include hypotension, bradycardia, AV block, dizziness, headache, nausea, flushing, edema, and transient elevation of liver enzymes. Serious adverse effects are more likely with rapid administration or overdose.

Pregnancy and Lactation

Verapamil may cause fetal hypoxia due to maternal hypotension. Intravenous use is not recommended during pregnancy unless the benefits clearly outweigh the risks. Verapamil is excreted in breast milk; therefore, breastfeeding should be discontinued during intravenous treatment.

Precautions and Warnings

Caution is required in patients with heart failure, bradycardia, mild AV block, or hepatic impairment. Verapamil may impair the ability to drive or operate machinery and can potentiate the effects of alcohol.

Storage

Store below 30°C. Protect from light. Keep out of reach of children.