Thalimide Capsule 100 mg contains Thalidomide, an immunomodulatory, anti-inflammatory, and anti-angiogenic agent used in the treatment of selected cancers and immune-mediated conditions. It is a high-risk medication that must only be used under strict medical supervision with controlled prescribing protocols.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Thalimide Capsule 100 mg is indicated for:

• Multiple myeloma (as part of combination chemotherapy regimens)
• Erythema nodosum leprosum (ENL)
• Selected inflammatory and autoimmune disorders (as directed by a specialist physician)

Mechanism of Action

Thalidomide exerts its therapeutic effects through multiple pathways:

• Suppression of tumor necrosis factor-alpha (TNF-α) production
• Modulation of immune system activity
• Inhibition of abnormal blood vessel formation (anti-angiogenesis)
• Regulation of inflammatory cytokines and immune response

These combined actions help reduce inflammation and inhibit disease progression in certain conditions.

Dosage and Administration

• Dosage is strictly individualized based on disease severity and clinical response.
• The capsule is usually taken once daily, preferably at bedtime to minimize drowsiness.
• Swallow the capsule whole with water, with or without food.
• Dose adjustments should only be made under medical supervision.

Benefits

• Effective in combination therapy for multiple myeloma
• Reduces inflammatory flare-ups in ENL
• Helps control abnormal immune responses
• Supports disease management in selected complex conditions

Side Effects

Common side effects may include:

• Drowsiness or sedation
• Fatigue
• Constipation
• Dizziness
• Skin rash

Serious side effects:

• Severe birth defects if used during pregnancy
• Peripheral neuropathy (numbness, tingling, nerve pain)
• Increased risk of blood clots (DVT, pulmonary embolism)
• Severe hypersensitivity reactions

Immediate medical attention is required if serious adverse effects occur.

Precautions and Warnings

• Strictly contraindicated during pregnancy due to severe teratogenic risk
• Mandatory pregnancy prevention program for women of childbearing potential
• Effective contraception must be used during and after treatment as advised
• Regular monitoring for neurological symptoms and thromboembolic events
• Use with caution in patients with liver disease or clotting disorders
• Avoid alcohol and sedative medications unless prescribed

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Thalimide Capsule 100 mg may interact with:

• Corticosteroids (increased risk of thrombosis)
• Sedatives and CNS depressants
• Anticoagulants
• Chemotherapy agents

Medical supervision is essential when used in combination therapy.

Storage

• Store below 25–30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.