Toco Injection 6.75 mg/0.9 ml contains Atosiban Acetate, a selective oxytocin receptor antagonist used in obstetric care to delay preterm labor. It helps relax uterine muscles and reduce uterine contractions, allowing prolongation of pregnancy under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Toco Injection is indicated for:

• Threatened preterm labor in pregnant women
• Short-term delay of preterm delivery in adults with regular uterine contractions
• Cervical dilation with uterine activity in preterm pregnancy (as assessed by a physician)

Mechanism of Action

Atosiban works by selectively blocking oxytocin receptors in the uterus. This leads to:

• Inhibition of oxytocin-induced uterine contractions
• Reduction in prostaglandin release
• Relaxation of uterine smooth muscle

These effects help delay premature labor and improve neonatal outcomes when used appropriately.

Dosage and Administration

• Administered as an intravenous injection/infusion under hospital supervision only
• Initial dose is usually given as a 6.75 mg IV bolus, followed by maintenance infusion as per clinical protocol
• Treatment duration is typically short-term (up to 48 hours)
• Must be used only by trained healthcare professionals

Benefits

• Helps delay preterm labor
• Improves time for fetal lung maturation with corticosteroid therapy
• Reduces risk of premature delivery-related complications
• Well-tolerated compared to some other tocolytic agents

Side Effects

Common side effects may include:

• Nausea
• Headache
• Dizziness
• Flushing
• Injection site reactions

Less common but serious side effects:

• Uterine bleeding
• Fetal heart rate changes (requires monitoring)
• Hypotension
• Allergic reactions

Precautions and Warnings

• For hospital use only under specialist supervision
• Not indicated if gestational age is beyond recommended limits for tocolysis
• Avoid use in cases of intrauterine fetal death or severe preeclampsia unless advised
• Continuous monitoring of maternal and fetal condition is required
• Use cautiously in patients with cardiovascular disease

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Toco Injection may interact with:

• Other tocolytic agents
• Antihypertensive drugs
• Oxytocin (functional antagonism)

Medical supervision is essential during use.

Storage

• Store below 25°C
• Protect from light
• Do not freeze
• Keep out of reach of children.