Trexonate Tablet 10 mg contains Methotrexate, a disease-modifying antirheumatic drug (DMARD) and antimetabolite used in the treatment of autoimmune disorders and certain cancers. It helps control abnormal immune activity, reduce inflammation, and slow disease progression.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Trexonate Tablet is indicated for:

• Rheumatoid arthritis (moderate to severe)
• Psoriasis and psoriatic arthritis
• Juvenile idiopathic arthritis
• Certain malignancies (as part of oncology protocols)
• Other autoimmune inflammatory disorders as prescribed by a specialist

Mechanism of Action

Methotrexate works by inhibiting the enzyme dihydrofolate reductase (DHFR), which is essential for DNA synthesis. This results in:

• Reduced proliferation of rapidly dividing cells
• Suppression of overactive immune responses
• Decreased production of inflammatory mediators

At low doses, it acts primarily as an immunomodulator, while at higher doses it has cytotoxic effects in cancer therapy.

Dosage and Administration

• Dosage must be strictly individualized and prescribed by a physician
• Commonly taken once weekly, not daily
• Must be taken exactly as directed to avoid toxicity
• Folic acid supplementation may be recommended to reduce side effects
• Regular laboratory monitoring is essential during therapy

Benefits

• Reduces joint pain, swelling, and stiffness in rheumatoid arthritis
• Helps control skin symptoms in psoriasis
• Slows progression of autoimmune diseases
• May be used in selected cancer treatment regimens
• Provides long-term disease control when properly monitored

Side Effects

Common side effects may include:

• Nausea and vomiting
• Mouth ulcers
• Fatigue
• Loss of appetite
• Hair thinning

Serious side effects:

• Liver toxicity
• Bone marrow suppression (low blood counts)
• Lung inflammation (methotrexate-induced pneumonitis)
• Increased susceptibility to infections

Precautions and Warnings

• Do not take daily unless specifically instructed by a physician
• Contraindicated in pregnancy and breastfeeding
• Regular monitoring of liver function, kidney function, and blood counts is required
• Avoid alcohol consumption due to risk of liver damage
• Use cautiously in patients with liver, kidney, or hematologic disorders
• Avoid live vaccines during treatment

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Trexonate Tablet may interact with:

• NSAIDs (increased risk of toxicity)
• Certain antibiotics (e.g., penicillins, sulfonamides)
• Other immunosuppressants
• Proton pump inhibitors (may increase methotrexate levels)

Medical supervision is essential when used with other medications.

Storage

• Store below 25°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.