Tricard MR Tablet 35 mg contains Trimetazidine Dihydrochloride, a metabolic anti-anginal agent used for managing chronic stable angina pectoris. Unlike traditional anti-anginals, Trimetazidine works by improving myocardial energy metabolism rather than altering heart rate or blood pressure. It enhances the heart’s tolerance to ischemia, reducing the frequency and severity of anginal attacks and improving overall cardiac function.

Tricard MR is formulated for modified-release, allowing once-daily dosing for consistent therapeutic effect, better adherence, and stable symptom control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Tricard MR Tablet is indicated for:

• Chronic stable angina pectoris as adjunct therapy
• Prevention of anginal attacks in patients with ischemic heart disease
• Improvement of exercise tolerance and reduction of symptoms in patients with refractory angina
• Supportive therapy in patients who cannot tolerate or achieve adequate control with traditional anti-anginal drugs

Mechanism of Action

Trimetazidine acts as a metabolic modulator:

• Optimizes cardiac energy metabolism by inhibiting fatty acid oxidation
• Promotes glucose utilization in myocardial cells, which requires less oxygen
• Improves myocardial efficiency during ischemic episodes
• Reduces angina symptoms without affecting heart rate, blood pressure, or myocardial contractility

This mechanism makes Tricard MR particularly useful for patients with comorbid conditions like hypotension or bradycardia.

Dosage and Administration

• Recommended dose: 1 tablet (35 mg) once daily, preferably at the same time each day
• Can be taken with or without food
• Do not crush, chew, or split the modified-release tablet
• Dose adjustment may be required in patients with renal impairment
• Continue therapy consistently for optimal angina control

Benefits

• Reduces the frequency and severity of anginal attacks
• Improves exercise tolerance and daily activity performance
• Provides myocardial protection during ischemia
• Once-daily modified-release formulation enhances adherence
• Safe for use in combination with other anti-anginal medications

Side Effects

Common side effects may include:

• Gastrointestinal disturbances (nausea, vomiting, abdominal discomfort)
• Headache or dizziness
• Mild fatigue

Rare but serious side effects:

• Movement disorders (tremor, rigidity, or Parkinsonian symptoms)
• Allergic reactions
• Skin rash or pruritus

Seek medical attention if movement disorders, severe dizziness, or allergic reactions occur.

Precautions and Warnings

• Use with caution in patients with Parkinson’s disease, tremors, or renal impairment
• Not recommended in patients with severe kidney dysfunction
• Pregnancy and breastfeeding: only use if clearly needed and prescribed by a doctor
• Monitor for signs of neurological adverse effects, especially in elderly patients
• Should be used as part of a comprehensive cardiovascular management plan, including diet and exercise

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Trimetazidine may interact with:

• Antihypertensives (generally safe but monitor for blood pressure changes)
• Other cardiac medications (usually safe; no direct negative interactions)
• Patients on multiple CNS-active drugs should be monitored for neurological symptoms

Always inform your healthcare provider about all medications and supplements before starting Tricard MR.

Storage

• Store below 25°C in a dry, cool place
• Protect from light and moisture
• Keep out of reach of children
• Do not use after the expiration date.