Triocim DS 50 ml is a double-strength oral suspension containing Cefixime, a third-generation cephalosporin antibiotic with proven in-vitro bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Its high stability against beta-lactamase enzymes makes it particularly effective in infections caused by bacteria resistant to penicillins and earlier cephalosporins.

Triocim DS 50 ml is formulated for pediatric use and is indicated for the treatment of various acute bacterial infections caused by susceptible microorganisms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Triocim DS 50 ml is indicated for the treatment of the following infections when caused by susceptible organisms:

• Upper Respiratory Tract Infections (URTI):
  Including otitis media and other URTIs where resistance to commonly used antibiotics is suspected or treatment failure may pose significant risk

• Lower Respiratory Tract Infections:
  Such as bronchitis

• Urinary Tract Infections (UTI):
  Including cystitis, cystourethritis, and pyelonephritis

• Typhoid fever (as per recommended dosing)

Clinical efficacy has been demonstrated against common pathogens such as Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (beta-lactamase positive and negative), Moraxella catarrhalis, and Enterobacter species.

Therapeutic Class

Third Generation Cephalosporins

Pharmacology

Cefixime is a third-generation semisynthetic cephalosporin antibiotic for oral administration. It exerts its bactericidal action by inhibiting bacterial cell wall synthesis. Due to its resistance to beta-lactamase enzymes, Cefixime remains effective against many organisms that are resistant to penicillins and some cephalosporins. Its oral absorption is approximately 40–50% and is not significantly affected by food.

Dosage and Administration

• Children (6 months or older):
  8 mg/kg/day administered as a single dose or in two divided doses
  General daily dosing guide:

  • 6 months to 1 year: 75 mg (3.75 ml) daily

  • 1–4 years: 100 mg (5 ml) daily

  • 5–10 years: 200 mg (10 ml) daily

  • 11–12 years: 300 mg daily

• Typhoid fever:
  5 mg/kg body weight twice daily for 10–14 days

• Children weighing more than 50 kg or older than 10 years:
  200–400 mg daily, similar to adult dosing

• Children under 6 months:
  Safety and efficacy have not been established

The usual treatment duration is 7 days, which may be extended up to 14 days depending on the severity of the infection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage in Renal Impairment

• Normal dosing may be used in patients with creatinine clearance ≥20 ml/min

• In patients with creatinine clearance <20 ml/min, the dose should not exceed 200 mg once daily

• The same recommendation applies to patients undergoing hemodialysis or peritoneal dialysis

Drug Interactions

As with other cephalosporins, prolonged prothrombin time has been reported in some patients. Caution is advised when Triocim DS 50 ml is used concomitantly with anticoagulant therapy.

Contraindications

Triocim DS 50 ml is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics.

Side Effects

Triocim DS 50 ml is generally well tolerated, and most adverse reactions are mild and self-limiting.

• Gastrointestinal: Diarrhea, stool changes, nausea, abdominal pain, dyspepsia, vomiting, flatulence; rare cases of pseudomembranous colitis

• Central Nervous System: Headache, dizziness

• Hypersensitivity: Rash, pruritus, urticaria, drug fever, arthralgia

• Hematological: Thrombocytopenia, leukopenia, eosinophilia (rare and reversible)

• Others: Transient changes in liver and renal function tests, genital pruritus, vaginitis

Pregnancy and Lactation

There are no adequate and well-controlled studies in pregnant women. Triocim DS 50 ml should be used during pregnancy only if clearly needed. It is not known whether Cefixime is excreted in human milk; therefore, caution should be exercised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients with a history of hypersensitivity to penicillins due to possible cross-reactivity

• Discontinue immediately if allergic reactions occur

• Use cautiously in patients with severe renal impairment

• Prolonged use may result in overgrowth of non-susceptible organisms, including Clostridium difficile

Overdose

There is no specific antidote for Cefixime overdose. Gastric lavage may be considered if necessary. Cefixime is not significantly removed by hemodialysis or peritoneal dialysis.

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of the reach of children.