Trisela Injection 300 mg/vial contains Trilaciclib, a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor used as a supportive therapy in oncology. It is administered prior to chemotherapy to protect bone marrow function and reduce chemotherapy-induced myelosuppression.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Trisela Injection is indicated for:

• Prevention of chemotherapy-induced bone marrow suppression
• Reduction of chemotherapy-related neutropenia
• Supportive care in small cell lung cancer patients receiving cytotoxic chemotherapy
• Other solid tumor chemotherapy regimens where myelosuppression risk is high (as prescribed by an oncologist)

Mechanism of Action

Trilaciclib works by transiently inhibiting CDK4/6 enzymes, leading to:

• Temporary arrest of hematopoietic stem cells in the G1 phase of the cell cycle
• Protection of bone marrow cells from chemotherapy-induced damage
• Reduced risk of neutropenia and anemia during chemotherapy

This mechanism helps improve patient tolerance to cancer treatment.

Dosage and Administration

• Administered as an intravenous infusion prior to chemotherapy
• Must be given under strict oncologist supervision
• Dose and timing depend on chemotherapy regimen and clinical protocol
• Should be administered within a defined time window before cytotoxic therapy
• Not used as a standalone anticancer treatment

Benefits

• Reduces risk of chemotherapy-induced neutropenia
• Helps maintain immune system function during cancer treatment
• May reduce need for growth factor support (e.g., G-CSF)
• Improves patient tolerance to chemotherapy
• Supports better continuity of cancer therapy schedules

Side Effects

Common side effects may include:

• Fatigue
• Headache
• Low calcium or phosphate levels
• Injection site reactions
• Transient liver enzyme elevation

Less common but serious side effects:

• Infusion-related reactions
• Severe hypersensitivity reactions
• Blood pressure changes
• Electrolyte imbalance

Precautions and Warnings

• For hospital and oncology use only
• Not a replacement for chemotherapy or cancer treatment
• Use under strict oncologist supervision
• Monitor blood counts and electrolytes regularly
• Use cautiously in patients with liver or kidney impairment
• Safety in pregnancy and breastfeeding not well established

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Trisela Injection may interact with:

• Chemotherapy agents (administered in sequence, not simultaneously)
• Other CDK4/6 inhibitors
• Drugs affecting liver metabolism

Careful scheduling with chemotherapy is required.

Storage

• Store below 25°C
• Protect from light
• Do not freeze
• Keep out of reach of children.