Turbocef 750 mg/Vial contains Cefuroxime, a second-generation cephalosporin antibiotic formulated for intramuscular or intravenous administration. It offers broad-spectrum bactericidal activity against a wide range of Gram-positive and Gram-negative organisms, including β-lactamase–producing strains. Turbocef 750 mg/Vial is especially useful in moderate to severe infections where parenteral therapy is required, as well as in surgical prophylaxis and serious systemic infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Second Generation Cephalosporins

Indications

Turbocef 750 mg/Vial is indicated for the treatment of infections caused by susceptible bacteria, including:

• Upper respiratory tract infections

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non β-lactamase producing strains)

• Ear infections

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (β-lactamase producing strains), or Streptococcus pyogenes

• Lower respiratory tract infections

  • Pneumonia caused by Streptococcus pneumoniae, Haemophilus influenzae (including β-lactamase producing strains), Klebsiella species, Staphylococcus aureus, Streptococcus pyogenes, and Escherichia coli

  • Acute bacterial exacerbation of chronic bronchitis

  • Secondary bacterial infections of acute bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae, or Haemophilus parainfluenzae

• Skin and soft tissue infections

  • Caused by Staphylococcus aureus (including β-lactamase producing strains) or Streptococcus pyogenes

• Urinary tract infections

  • Caused by Escherichia coli or Klebsiella pneumoniae

• Bone and joint infections

  • Caused by Staphylococcus aureus (penicillinase- and non-penicillinase-producing strains)

• Sexually transmitted infections

  • Gonorrhoea caused by penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae

• Other serious infections

  • Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

  • Meningitis

  • Surgical prophylaxis to prevent postoperative infections

Pharmacology

Cefuroxime exerts its antibacterial effect by inhibiting bacterial cell wall synthesis, leading to bacterial cell death. It is highly stable against β-lactamase enzymes and remains effective against many ampicillin- and amoxicillin-resistant organisms.

Dosage and Administration

Parenteral Administration (IM or IV):

Adults:

• Standard dose: 750 mg three times daily

• Severe infections: Up to 1.5 g three times daily

• Meningitis: 3 g IV three times daily

• Bone and joint infections: 1.5 g IV four times daily

• Gonorrhoea: 1.5 g as a single dose (two 750 mg IM injections at different sites)

Children (above 3 months):

• 30–100 mg/kg/day in 3–4 divided doses

• Meningitis: 200–240 mg/kg/day initially, reduced to 100 mg/kg/day after improvement

Neonates:

• 30–100 mg/kg/day in 2–3 divided doses

Dosage and duration depend on the severity of infection and the patient’s clinical condition.

Administration

Freshly reconstituted solution is recommended. After reconstitution, the solution retains potency for at least 24 hours at room temperature or up to 48 hours when stored at 5°C.

Contraindications

Turbocef 750 mg/Vial is contraindicated in patients with known hypersensitivity to cefuroxime or other cephalosporin antibiotics.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Adverse reactions are generally mild and transient and may include:

• Gastrointestinal disturbances

• Skin rashes

• Overgrowth of non-susceptible organisms such as Candida with prolonged use

Drug Interactions

No clinically significant or potentially hazardous drug interactions have been reported.

Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly necessary. Cefuroxime is excreted in breast milk; caution is advised when administered to nursing mothers.

Precautions and Warnings

• Use with caution in patients with a history of colitis

• Caution is advised when used with potent diuretics

• Possible cross-reactivity in patients with penicillin hypersensitivity

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.