Valex CR Tablet 200 mg is a controlled-release formulation of Sodium Valproate, developed to provide long-lasting antiepileptic effects with reduced gastrointestinal side effects and convenient once or twice-daily dosing. Sodium Valproate is a broad-spectrum antiepileptic drug that works by enhancing gamma-aminobutyric acid (GABA) activity, the primary inhibitory neurotransmitter in the central nervous system. By increasing GABA levels, Valex CR stabilizes neuronal firing and helps prevent seizures.

The controlled-release (CR) technology ensures steady plasma drug levels, minimizing fluctuations and reducing the risk of breakthrough seizures. Valex CR is ideal for adults and children who require consistent seizure control and prefer a simpler dosing regimen. It is also indicated for bipolar disorder and migraine prophylaxis.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Primary Anti-Epileptic Drugs

Indications

Valex CR Tablet 200 mg is indicated for:

• Epilepsy:

  • Partial seizures

  • Absence seizures (petit mal)

  • Generalized tonic-clonic seizures (grand mal)

  • Myoclonic seizures

  • Atonic seizures

  • Mixed seizures including absence attacks

• Prophylaxis of febrile convulsions

• Prophylaxis of post-traumatic epilepsy

• Bipolar disorder (mood stabilization)

• Prophylaxis of migraine

The CR formulation is particularly suitable for patients who benefit from stable blood levels and reduced gastrointestinal irritation.

Pharmacology

Sodium Valproate in Valex CR works by increasing GABA concentrations in the brain, which enhances inhibitory neurotransmission and reduces neuronal hyperexcitability. This action helps control seizures across multiple types of epilepsy.

Pharmacokinetics:

• Absorption: CR formulation ensures gradual drug release for steady plasma levels

• Metabolism: Primarily hepatic

• Excretion: Partially in urine

• Half-life: 9–16 hours in adults; may vary in children

Dosage and Administration

Adults:

• Initial dose: 600 mg/day in 1–2 divided doses after food

• Titration: Increase by 200 mg/day every 3 days as needed

• Maintenance: 1–2 g/day (20–30 mg/kg/day), up to 2.5 g/day

Children:

• Up to 20 kg: 20 mg/kg/day in divided doses

• Over 20 kg: Initial 400 mg/day, titrated up to 20–35 mg/kg/day

Special Uses:

• Febrile convulsions: 20–30 mg/kg/day in 3 divided doses

• Bipolar disorder: 600 mg/day initially, maintenance 1–2 g/day

• Migraine prophylaxis: 400–600 mg/day

Administration Tips:

• Swallow CR tablets whole; do not crush or chew

• Take with food to reduce gastrointestinal discomfort

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Interactions

Valex CR may interfere with drug metabolism, affecting:

• Phenobarbital

• Phenytoin

• Warfarin

• Aspirin

Close monitoring may be required to avoid adverse reactions.

Contraindications

• Known hypersensitivity to Sodium Valproate

• Liver dysfunction

• Pregnancy or women of childbearing potential unless necessary

Side Effects

Common side effects include:

• Gastrointestinal: nausea, vomiting, anorexia (less frequent than immediate-release forms)

• CNS: sedation, tremor, ataxia

• Dermatologic: rash, alopecia

• Rare: hepatic injury, pancreatitis, hyperammonemia

Routine monitoring of liver function and plasma levels is recommended.

Precautions

• Avoid sudden discontinuation to prevent seizure recurrence

• Monitor liver function during the first 6 months

• Adjust dosing in renal impairment

• Avoid use in systemic lupus erythematosus

Pregnancy and Lactation

• Crosses the placenta; exposure in the first trimester may cause neural tube defects

• Excreted in breast milk; caution advised

Storage

• Store below 30°C, away from light

• Keep out of reach of children

Mode of Action

Valex CR increases GABA levels in the brain, enhancing inhibitory neurotransmission, stabilizing neuronal firing, and effectively controlling multiple types of seizures.