Valex Injection 500 mg/5 ml is an intravenous formulation of Sodium Valproate, designed for the management of epilepsy and seizure disorders when oral administration is not feasible. This injectable preparation provides rapid and effective control of seizures, making it suitable for acute episodes, status epilepticus, or patients unable to take oral medication.

Valex Injection works by enhancing gamma-aminobutyric acid (GABA) levels in the brain, stabilizing neuronal activity, and reducing the frequency and intensity of seizures. It is also indicated for bipolar disorder management, prophylaxis of migraine, and febrile convulsions. The solution is formulated for intravenous slow injection or infusion, ensuring safe and effective systemic delivery.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Primary Anti-Epileptic Drugs

Indications

Valex Injection 500 mg/5 ml is indicated for:

• Acute management of epilepsy and seizure disorders

• Status epilepticus or prolonged convulsive episodes

• Bipolar disorder for rapid stabilization of mood

• Prophylaxis of migraine

• Febrile convulsions in pediatric patients

• Post-traumatic epilepsy prevention

Pharmacology

Sodium Valproate, the active ingredient in Valex Injection, exerts its antiepileptic effect by increasing GABA concentrations in the central nervous system, enhancing inhibitory neurotransmission, and stabilizing neuronal firing.

Mechanism of Action:

• Increases brain GABA levels

• Reduces abnormal electrical activity in neurons

• Provides broad-spectrum seizure control across partial, generalized, myoclonic, atonic, and absence seizures

Pharmacokinetics:

• Rapid systemic absorption via intravenous route

• Metabolized in the liver, partially excreted in urine

• Half-life: approximately 9–16 hours in adults

Dosage and Administration

Adults:

• Initial dose: 400–800 mg IV over 3–5 minutes, depending on body weight

• Maximum daily dose: 2.5 g

• Can be administered as slow intravenous injection or continuous infusion

Children:

• Initial dose: 20–30 mg/kg/day IV

• Maximum: 40 mg/kg/day

• Dosing can be adjusted according to clinical response and plasma drug levels

Administration Guidelines:

• Administer slowly to avoid cardiovascular adverse effects

• Use compatible diluents such as 0.9% Sodium Chloride or 5% Dextrose

• Monitor for sedation, hypotension, and other potential adverse effects during infusion

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Sodium Valproate or related compounds

• Severe liver dysfunction or hepatic disease

• Pregnancy (particularly in the first trimester) unless benefits outweigh risks

Side Effects

Common adverse effects include:

• Gastrointestinal: nausea, vomiting

• CNS: sedation, tremor, dizziness

• Rare but serious: hepatotoxicity, pancreatitis, hyperammonemia

• Dermatologic: rash, alopecia

Frequent monitoring of liver function tests, plasma levels, and coagulation parameters is recommended during therapy.

Precautions

• Adjust dose in renal impairment

• Avoid abrupt discontinuation to prevent seizure recurrence

• Use with caution in patients on multiple antiepileptic drugs

• Monitor for CNS depression or sedation during IV administration

Pregnancy and Lactation

• Pregnancy: Crosses the placenta; associated with neural tube defects (anencephaly, spina bifida)

• Lactation: Excreted in breast milk; caution advised

Storage

• Store below 30°C, away from light

• Keep out of reach of children

• Do not freeze

Mode of Action

Valex Injection increases GABAergic activity in the brain, stabilizing neuronal excitability and providing broad-spectrum seizure control, suitable for both acute and chronic management of epilepsy.