Valex Syrup 200 mg/5 ml is a liquid oral formulation of Sodium Valproate, designed for the treatment of epilepsy, bipolar disorder, and migraine prophylaxis, particularly for children or patients who have difficulty swallowing tablets. Sodium Valproate is a broad-spectrum antiepileptic drug that works by enhancing the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system, thereby stabilizing neuronal activity and preventing seizures.

Valex Syrup offers accurate dosing, ease of administration, and flexibility, making it suitable for pediatric patients and for situations requiring adjustable dose titration. The syrup formulation ensures better compliance in patients who are unable to take solid oral dosage forms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Primary Anti-Epileptic Drugs

Indications

Valex Syrup 200 mg/5 ml is indicated for:

• Epilepsy:

  • Partial seizures

  • Absence seizures (petit mal)

  • Generalized tonic-clonic seizures (grand mal)

  • Myoclonic seizures

  • Atonic seizures

  • Mixed seizures including absence attacks

• Prophylaxis of febrile convulsions

• Prophylaxis of post-traumatic epilepsy

• Bipolar disorder (mood stabilization)

• Prophylaxis of migraine

The syrup is particularly useful in children, allowing precise weight-based dosing and easy administration.

Pharmacology

Sodium Valproate enhances GABAergic neurotransmission in the brain, which increases inhibitory activity and stabilizes electrical activity, reducing the frequency and severity of seizures.

Mechanism of Action:

• Increases brain levels of GABA, the primary inhibitory neurotransmitter

• Reduces neuronal hyperexcitability

• Controls seizures across multiple types of epilepsy

Pharmacokinetics:

• Well absorbed orally; peak plasma concentrations achieved within 1–4 hours

• Metabolized in the liver; partially excreted in urine

• Half-life: 9–16 hours in adults, shorter in children

Dosage and Administration

Adults:

• Initial: 600 mg/day in 2 divided doses after food

• Titration: Increase by 200 mg/day every 3 days as needed

• Maintenance: 1–2 g/day (20–30 mg/kg/day), up to 2.5 g/day

Children:

• Up to 20 kg: 20 mg/kg/day in divided doses

• Over 20 kg: Initial 400 mg/day, titrated to 20–35 mg/kg/day

• Febrile convulsions: 20–30 mg/kg/day in 3 divided doses

Administration Tips:

• Shake the bottle well before use

• Measure the dose using a calibrated measuring device

• Administer after meals to reduce gastrointestinal discomfort

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Interactions

Valex Syrup can inhibit drug metabolism, affecting:

• Phenobarbital

• Phenytoin

• Warfarin

• Aspirin

Close monitoring is recommended to avoid adverse effects or toxicity.

Contraindications

• Known hypersensitivity to Sodium Valproate

• Liver dysfunction

• Pregnancy or women of childbearing potential, unless clearly indicated

Side Effects

• Gastrointestinal: nausea, vomiting, anorexia

• CNS: sedation, tremor, ataxia

• Dermatologic: rash, alopecia

• Rare: hepatic injury, pancreatitis, hyperammonemia

Routine monitoring of liver function and plasma levels is recommended, especially in young children or those on multiple antiepileptic drugs.

Precautions

• Avoid sudden withdrawal to prevent seizures

• Monitor liver function, especially in children under 2 years

• Adjust dose in renal impairment

• Avoid use in systemic lupus erythematosus

Pregnancy and Lactation

• Crosses the placenta; associated with neural tube defects if exposed in the first trimester

• Excreted in breast milk; caution advised

Storage

• Store below 30°C, protected from light

• Keep out of reach of children

Mode of Action

Valex Syrup increases GABA activity in the brain, enhancing inhibitory neurotransmission, which stabilizes neuronal firing and controls various types of seizures effectively.