Varipress Injection 1 mg/8.5 ml contains Terlipressin Acetate, a synthetic vasopressin analogue used in the emergency management of severe gastrointestinal bleeding and certain liver-related complications. It acts by constricting blood vessels and reducing portal venous pressure, helping control bleeding effectively in critical conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Varipress Injection is indicated for:

• Acute esophageal variceal bleeding
• Bleeding related to portal hypertension
• Hepatorenal syndrome (type 1)
• Supportive management in severe liver cirrhosis complications
• Control of gastrointestinal hemorrhage (as per physician’s decision)

Mechanism of Action

Terlipressin is a vasopressin receptor agonist that causes:

• Constriction of splanchnic (abdominal) blood vessels
• Reduction in portal venous pressure
• Decreased blood flow to varices, helping control bleeding
• Improved renal perfusion in hepatorenal syndrome

It acts as a prodrug and is slowly converted to active lysine vasopressin, providing sustained effect.

Dosage and Administration

• Administered intravenously or as a slow IV injection under hospital supervision only
• Initial dose is typically 1 mg every 4–6 hours, adjusted based on response
• Treatment duration depends on clinical condition and bleeding control
• Must be used in intensive care or emergency settings with continuous monitoring

Benefits

• Rapid control of acute variceal bleeding
• Reduces portal hypertension effectively
• Improves survival in severe liver-related bleeding emergencies
• Useful in management of hepatorenal syndrome
• Provides targeted vascular constriction in splanchnic circulation

Side Effects

Common side effects may include:

• Abdominal cramps
• Nausea
• Diarrhea
• Headache
• Pale skin or transient blood pressure changes

Serious side effects:

• Cardiac ischemia (chest pain, reduced blood flow to heart)
• Hypertension or hypotension
• Bradycardia (slow heart rate)
• Peripheral ischemia
• Respiratory complications

Precautions and Warnings

• For hospital and emergency use only
• Continuous monitoring of blood pressure and heart function is required
• Use cautiously in patients with coronary artery disease or cardiovascular disorders
• Not recommended in pregnancy unless life-saving
• Dose adjustment may be needed in elderly or critically ill patients
• Careful monitoring is essential during infusion

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Varipress Injection may interact with:

• Beta-blockers (additive cardiovascular effects)
• Vasoconstrictive agents
• Diuretics (may affect electrolyte balance)
• Other drugs affecting cardiac function

Strict medical supervision is required when used with other therapies.

Storage

• Store below 25°C
• Protect from light
• Do not freeze
• Keep out of reach of children.