Ximeprox Suspension 40 mg/5 ml is an oral antibiotic formulation containing Cefpodoxime Proxetil, a third-generation cephalosporin with broad-spectrum antibacterial activity. It is specifically designed for pediatric patients and infants but may also be used in adolescents under medical supervision. Ximeprox Suspension is effective against a variety of Gram-positive and Gram-negative bacteria and is commonly prescribed for respiratory, ear, skin, urinary tract, and other bacterial infections.

Cefpodoxime Proxetil is a prodrug, which is converted in the body to active cefpodoxime after oral administration. Its stability against beta-lactamase enzymes makes it effective against many resistant bacterial strains.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Third Generation Cephalosporins

Indications

Ximeprox Suspension 40 mg/5 ml is indicated for the treatment of infections caused by susceptible microorganisms, including:

• Acute otitis media caused by Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis (including beta-lactamase-producing strains)

• Pharyngitis and tonsillitis caused by Streptococcus pyogenes

• Acute maxillary sinusitis caused by Haemophilus influenzae (including beta-lactamase-producing strains), Streptococcus pneumoniae, and Moraxella catarrhalis

• Community-acquired pneumonia caused by S. pneumoniae or H. influenzae (including beta-lactamase-producing strains)

• Acute bacterial exacerbations of chronic bronchitis caused by S. pneumoniae, H. influenzae (non-beta-lactamase-producing strains), or M. catarrhalis

• Skin and soft tissue infections caused by Staphylococcus aureus and Streptococcus pyogenes

• Uncomplicated urinary tract infections caused by E. coli, Klebsiella pneumoniae, Proteus mirabilis, or Staphylococcus saprophyticus

• Uncomplicated gonorrhea caused by Neisseria gonorrhoeae (including penicillinase-producing strains)

• Rectal gonococcal infections in women caused by Neisseria gonorrhoeae

Pharmacology

Cefpodoxime Proxetil is absorbed from the gastrointestinal tract and hydrolyzed to its active metabolite, cefpodoxime, which inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This results in bacterial cell lysis and death. About 29–33% of cefpodoxime is excreted unchanged in urine within 12 hours, and the drug demonstrates good activity against both Gram-positive and Gram-negative organisms.

Mode of Action

• Inhibits bacterial cell wall synthesis

• Binds to penicillin-binding proteins

• Leads to bacterial cell lysis and death

• Effective against a broad range of susceptible pathogens

Dosage and Administration

Adults and Adolescents (≥13 years):

• Pharyngitis/tonsillitis: 100 mg every 12 hours for 5–10 days

• Acute maxillary sinusitis: 200 mg every 12 hours for 10 days

• Community-acquired pneumonia: 200 mg every 12 hours for 14 days

• Acute bacterial exacerbation of chronic bronchitis: 200 mg every 12 hours for 10 days

• Skin and skin structure infections: 400 mg every 12 hours for 7–14 days

• Uncomplicated urinary tract infection: 100 mg every 12 hours for 7 days

• Uncomplicated gonorrhea: single dose of 200 mg

• Rectal gonococcal infection in women: single dose of 200 mg

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Infants and Pediatric Patients (2 months – 12 years):

• Acute otitis media: 5 mg/kg every 12 hours for 5 days

• Pharyngitis/tonsillitis: 5 mg/kg every 12 hours for 5–10 days

• Acute maxillary sinusitis: 5 mg/kg every 12 hours for 10 days

Administration Instructions (Suspension Reconstitution):

1. Shake the bottle well to loosen the powder

2. Add boiled and cooled water to the mark

3. Shake until the powder is fully dissolved

4. Administer using the provided measuring device for accurate dosing

Drug Interactions

• Antacids containing sodium bicarbonate or aluminum hydroxide, and H2 blockers, may reduce absorption

• Probenecid can inhibit renal excretion of cefpodoxime, increasing plasma levels

Contraindications

• Hypersensitivity to cefpodoxime, cephalosporins, or any component of the formulation

Side Effects

Cefpodoxime is generally well tolerated. Possible side effects include:

• Gastrointestinal disorders: diarrhea, nausea, vomiting, abdominal pain

• Skin reactions: rash, urticaria, itching

Pregnancy and Lactation

• US FDA Pregnancy Category B

• Use during pregnancy only if clearly needed

• Cefpodoxime is excreted in human breast milk; caution is advised when administered to nursing mothers

Precautions and Warnings

• Adjust dosage in patients with renal insufficiency

• Use with caution in patients receiving potent diuretics

• Prolonged therapy may result in overgrowth of non-susceptible organisms

Use in Special Populations

• Severe renal impairment (creatinine clearance <30 ml/min): increase dosing interval to 24 hours

• Hepatic impairment: no dosage adjustment required

Storage Conditions

• Store in a dry place away from heat and light

• Keep out of reach of children.