A-Cof Syrup is a combination cough and cold preparation containing Dextromethorphan Hydrobromide, Pseudoephedrine Hydrochloride, and Triprolidine Hydrochloride. This well-balanced formulation is designed to provide effective relief from dry cough, nasal congestion, runny nose, sneezing, and other upper respiratory tract symptoms associated with common cold, flu, sinusitis, and allergic rhinitis. A-Cof Syrup helps patients breathe easier and feel more comfortable during respiratory infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

A-Cof Syrup is indicated for the symptomatic relief of:

• Dry, non-productive cough

• Nasal congestion

• Runny nose (rhinorrhea)

• Sneezing

• Allergic rhinitis

• Common cold and influenza

• Sinus congestion and pressure

It is especially useful when cough is accompanied by nasal and allergic symptoms.

Therapeutic Class

Cough and cold preparations

Pharmacology

A-Cof Syrup combines three active ingredients with complementary actions:

• Dextromethorphan Hydrobromide is a centrally acting antitussive that suppresses the cough reflex by acting on the cough center in the medulla. It effectively reduces the frequency and intensity of dry cough without causing significant respiratory depression at therapeutic doses.

• Pseudoephedrine Hydrochloride is a sympathomimetic decongestant that acts on alpha-adrenergic receptors, causing vasoconstriction of nasal blood vessels. This reduces swelling and congestion of the nasal mucosa, improving airflow and relieving nasal blockage.

• Triprolidine Hydrochloride is a first-generation antihistamine that blocks H1 receptors, helping to relieve allergic symptoms such as sneezing, runny nose, and watery eyes. Its mild sedative effect may also help reduce discomfort associated with cold symptoms.

Together, these agents provide comprehensive relief from cough and upper respiratory tract symptoms.

Mode of Action

A-Cof Syrup suppresses the cough reflex through central action, relieves nasal congestion by vasoconstriction of swollen mucosa, and counteracts histamine-mediated allergic symptoms. This multimodal approach ensures effective and sustained symptom control.

Dosage and Administration

Dosage should be taken as directed by a physician:

• Adults and children over 12 years: 5–10 ml, two to three times daily

• Children: Dose adjusted according to age and body weight

The syrup should be measured using a proper measuring device. Duration of use should be limited to the shortest period necessary to control symptoms.

Drug Interactions

Caution is advised when used with monoamine oxidase inhibitors, antidepressants, sedatives, or other sympathomimetic agents. Concurrent use with alcohol may enhance sedative effects. Patients with chronic conditions should consult a healthcare professional before use.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

A-Cof Syrup is contraindicated in patients with:

• Hypersensitivity to any component of the formulation

• Severe hypertension or coronary artery disease

• Narrow-angle glaucoma

• Concurrent use of monoamine oxidase inhibitors

Side Effects

A-Cof Syrup is generally well tolerated. Possible side effects include:

• Drowsiness or dizziness

• Dry mouth

• Gastrointestinal discomfort

• Restlessness or insomnia due to pseudoephedrine

Side effects are usually mild and transient when taken at recommended doses.

Pregnancy and Lactation

The use of A-Cof Syrup during pregnancy and lactation should be based on a physician’s assessment of benefit versus risk. Medical advice is recommended before use.

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.