Acos 500 mg Tablet is a macrolide antibiotic belonging to the azalide subgroup. It is widely prescribed for the treatment of various bacterial infections caused by susceptible organisms. Acos works by inhibiting bacterial protein synthesis, thereby preventing the growth and multiplication of infection-causing bacteria.

This antibiotic is effective against a broad range of gram-positive and gram-negative bacteria, as well as certain atypical pathogens. It is commonly used for respiratory tract infections, skin infections, and specific sexually transmitted diseases.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Macrolide Antibiotic (Azalide group)

Indications

Acos 500 mg is indicated for the treatment of infections caused by susceptible microorganisms, including:

• Upper respiratory tract infections such as sinusitis and pharyngitis/tonsillitis

• Lower respiratory tract infections including bronchitis and pneumonia

• Otitis media

• Skin and soft tissue infections

• Non-gonococcal urethritis and cervicitis caused by Chlamydia trachomatis

• Certain sexually transmitted infections in men and women

• Typhoid fever (as prescribed)

Pharmacology

Acos 500 mg acts by binding to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting microbial protein synthesis. This action prevents bacterial growth and replication.

It demonstrates activity against a wide range of organisms including:

• Gram-positive bacteria such as Streptococcus and Staphylococcus aureus

• Gram-negative bacteria including Haemophilus influenzae, Moraxella catarrhalis, and Neisseria gonorrhoeae

• Atypical pathogens such as Mycoplasma pneumoniae and Legionella pneumophila

• Other organisms including Campylobacter species and Treponema pallidum

Dosage and Administration

Adults:

• 500 mg once daily for 3 days
  OR

• 500 mg on Day 1, followed by 250 mg once daily on Days 2–5

For sexually transmitted infections caused by Chlamydia trachomatis:

• 1 g as a single dose
  OR

• 500 mg on Day 1, followed by 250 mg once daily for the next 2 days

Children (Over 6 months):

• 10 mg/kg body weight once daily for 3 days

Specific dosing according to body weight:

• 15–25 kg: 200 mg once daily for 3 days

• 26–35 kg: 300 mg once daily for 3 days

• 36–45 kg: 400 mg once daily for 3 days

For typhoid fever:

• 500 mg once daily for 7–10 days (as directed by physician)

Administration Instructions (For Suspension)

1. Shake the bottle thoroughly to loosen the powder.

2. Add boiled and cooled water up to the marked line.

3. Shake well until fully mixed.

Take Acos 500 mg at least 1 hour before or 2 hours after meals.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Food and antacids may reduce absorption.

• Avoid concomitant use with ergot alkaloids due to risk of ergotism.

• Use caution when co-administered with cyclosporine or digoxin as plasma levels may increase.

• No significant interaction reported with warfarin, theophylline, carbamazepine, methylprednisolone, or cimetidine.

Contraindications

• Hypersensitivity to Acos or other macrolide antibiotics

• Concurrent use with ergot derivatives

• Patients with significant liver disorders

Side Effects

Side effects are generally mild and reversible. These may include:

• Nausea

• Vomiting

• Abdominal pain or cramps

• Diarrhea

• Flatulence

• Headache

• Skin rash

Pregnancy and Lactation

• Pregnancy Category B

• Use during pregnancy only if clearly needed and no suitable alternative is available.

• Caution is advised during breastfeeding as excretion in breast milk is unknown.

Precautions and Warnings

• Monitor for signs of superinfection (e.g., fungal infection) during prolonged use.

• No dose adjustment is required in patients with renal impairment.

• Use cautiously in patients with liver dysfunction.

Overdose

Symptoms of macrolide overdose may include hearing loss, severe nausea, vomiting, and diarrhea. Gastric lavage and supportive management are recommended.

Storage Conditions

• Store in a cool, dry place away from heat and light.

• Keep out of reach of children.