Admira MR Tablet 60 mg is a modified-release formulation containing Gliclazide 60 mg, an oral antidiabetic medication for the management of type 2 diabetes mellitus. As a member of the sulfonylurea class, Gliclazide lowers blood glucose levels by stimulating the pancreas to release insulin. The modified-release (MR) formulation allows for once-daily dosing, providing more consistent blood glucose control over 24 hours and improving patient adherence.

Admira MR 60 mg is intended for patients who are inadequately controlled with diet, exercise, or standard antidiabetic therapy. It may be used alone or in combination with other antidiabetic agents such as metformin to achieve optimal glycemic control. The MR formulation helps maintain stable blood sugar levels throughout the day and reduces the risk of hypoglycemic peaks associated with immediate-release formulations.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Gliclazide 60 mg (Modified Release)

Mechanism of Action

Gliclazide works by stimulating pancreatic beta cells to produce and release insulin in response to elevated blood glucose. It binds to sulfonylurea receptors on the beta cells, enhancing insulin secretion.

Key effects of Gliclazide include:

• Lowering fasting blood glucose

• Reducing postprandial (after-meal) glucose spikes

• Improving long-term glycemic control (HbA1c reduction)

The modified-release formulation ensures a gradual release of the active ingredient, providing a smoother, more sustained insulin release. Additionally, Gliclazide may have vascular protective effects, improving endothelial function and reducing platelet aggregation, which can help decrease cardiovascular risk in diabetic patients.

Indications

Admira MR Tablet 60 mg is indicated for:

• Management of Type 2 Diabetes Mellitus

• Patients not adequately controlled with lifestyle modifications alone

• Monotherapy for suitable patients

• Combination therapy with metformin or insulin when additional glycemic control is needed

• Patients who require more stable blood glucose control throughout the day

Benefits

• Once-Daily Dosing: Improves adherence and convenience for patients

• Effective Blood Sugar Control: Reduces fasting and postprandial glucose levels

• HbA1c Reduction: Supports long-term glycemic management

• Cardiovascular Support: May help improve vascular function

• Reduced Hypoglycemia Risk: Compared to immediate-release formulations when taken as directed

• Flexible Therapy Options: Can be used alone or in combination with other antidiabetic medications

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

Admira MR Tablet 60 mg is usually taken once daily, preferably with breakfast. The modified-release tablet should be swallowed whole with water and not crushed or chewed, to maintain the sustained-release effect.

The exact dosage should be determined by a healthcare professional based on blood glucose levels and patient response. Regular monitoring of blood sugar, HbA1c, and kidney and liver function is recommended.

Safety and Precautions

• Risk of hypoglycemia, particularly if meals are skipped or delayed

• Use cautiously in elderly patients and those with renal or hepatic impairment

• Symptoms of low blood sugar may include sweating, dizziness, tremors, or palpitations

• Mild weight gain may occur in some patients

• Not recommended for Type 1 diabetes or diabetic ketoacidosis

Patients should inform their healthcare provider about all medications and underlying conditions before starting Admira MR 60 mg. Proper supervision and routine follow-up are essential for safe and effective diabetes management.