A-Flox IM/IV Injection 500 mg/vial contains Flucloxacillin Sodium, a penicillinase-resistant beta-lactam antibiotic intended for intramuscular or intravenous administration. This injectable formulation is used in the treatment of moderate to severe infections caused by susceptible Gram-positive bacteria, particularly penicillin-resistant Staphylococcus aureus. It is especially valuable in hospitalized patients or in situations where oral therapy is not appropriate or effective.

A-Flox Injection provides rapid onset of antibacterial action and high systemic drug levels, making it suitable for serious and life-threatening infections that require parenteral antibiotic therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Flucloxacillin Sodium BP equivalent to Flucloxacillin 500 mg

Therapeutic Class

• Beta-lactam antibiotic

• Penicillinase-resistant penicillin

Indications

A-Flox IM/IV Injection 500 mg/vial is indicated for the treatment of infections caused by flucloxacillin-sensitive organisms, including:

Severe Skin and Soft Tissue Infections

• Cellulitis

• Abscesses

• Infected wounds

• Severe skin infections requiring parenteral therapy

Bone and Joint Infections

• Osteomyelitis

• Septic arthritis

Respiratory Tract Infections

• Severe pneumonia

• Acute exacerbations of chronic bronchitis

Systemic and Other Infections

• Septicemia

• Endocarditis (as part of combination therapy)

• Post-operative and surgical site infections

Surgical Prophylaxis

• Prevention of staphylococcal infections during high-risk surgical procedures, as advised by a healthcare professional

Mechanism of Action

Flucloxacillin works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins within the bacterial cell wall, blocking the final stages of peptidoglycan formation. This weakens the bacterial cell wall, leading to cell lysis and bacterial death.

A distinguishing feature of Flucloxacillin is its resistance to beta-lactamase enzymes produced by many staphylococcal strains. This allows A-Flox IM/IV Injection to remain effective against penicillin-resistant staphylococci, making it a preferred choice in serious Gram-positive infections.

Dosage and Administration

A-Flox IM/IV Injection 500 mg/vial should be administered by intramuscular injection or intravenous injection/infusion, strictly under the supervision of a qualified healthcare professional. The dose, frequency, and duration of treatment depend on the type and severity of the infection, patient age, body weight, and renal function.

For intravenous use, the powder should be reconstituted with a suitable diluent and administered as directed. Patients may be switched to oral flucloxacillin therapy once clinical improvement is observed.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Contraindicated in patients with a history of hypersensitivity to penicillins or beta-lactam antibiotics.

• Use with caution in patients with hepatic dysfunction, as flucloxacillin may rarely cause cholestatic hepatitis.

• Prolonged therapy requires monitoring of liver and kidney function.

Possible Side Effects

Common side effects may include:

• Injection site pain or inflammation

• Nausea or vomiting

• Diarrhea

Rare but serious adverse reactions include allergic reactions, liver enzyme elevation, and blood disorders. Immediate medical attention is required if severe reactions occur.

Storage Conditions

Store below 25°C in a dry place. Protect from light. Reconstituted solution should be used immediately or as directed by healthcare guidelines.