Janvia Tablet 50 mg contains Sitagliptin, an oral antidiabetic medication used for the management of Type 2 Diabetes Mellitus. It belongs to the class of drugs known as DPP-4 (Dipeptidyl Peptidase-4) inhibitors, which help improve blood sugar control by enhancing the body’s natural incretin system. Janvia 50 mg is prescribed for adults whose blood glucose levels are not adequately controlled by diet and exercise alone or in combination with other antidiabetic medications.

Type 2 diabetes is a chronic metabolic condition characterized by insulin resistance and impaired insulin secretion. Persistently high blood sugar levels can lead to serious complications such as cardiovascular disease, kidney damage, nerve disorders, and vision impairment. Janvia helps lower blood glucose levels in a glucose-dependent manner, reducing the risk of hypoglycemia compared to some other antidiabetic drugs.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each film-coated tablet contains:

• Sitagliptin 50 mg (as Sitagliptin Phosphate)

Mechanism of Action

Sitagliptin works by inhibiting the DPP-4 enzyme, which is responsible for breaking down incretin hormones such as GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide). By blocking DPP-4:

• Incretin hormone levels increase

• Insulin secretion from pancreatic beta cells increases in response to meals

• Glucagon secretion from alpha cells decreases

• Hepatic glucose production is reduced

Because its action is glucose-dependent, Sitagliptin primarily works when blood sugar levels are elevated, minimizing the risk of excessive hypoglycemia.

Indications

Janvia Tablet 50 mg is indicated for:

• Management of Type 2 Diabetes Mellitus in adults

• Monotherapy when diet and exercise are insufficient

• Combination therapy with Metformin, sulfonylureas, insulin, or other antidiabetic agents

• Patients requiring improved glycemic control with a low risk of hypoglycemia

It is not indicated for Type 1 diabetes or diabetic ketoacidosis.

Dosage and Administration

The usual recommended dose is 50 mg once daily, or as prescribed by a healthcare professional. Dose adjustment may be required in patients with renal impairment. The tablet can be taken with or without food and should be swallowed whole with water.

Regular monitoring of blood glucose and HbA1c levels is advised to assess treatment effectiveness.

Benefits

• Effective control of postprandial and overall blood glucose levels

• Low risk of hypoglycemia when used alone

• Weight-neutral therapy

• Convenient once-daily dosing

• Suitable for combination with other antidiabetic medications

Precautions

• Assess kidney function before and during therapy

• Use cautiously in patients with a history of pancreatitis

• Inform the doctor about all current medications to avoid interactions

• Not recommended during pregnancy or breastfeeding unless advised

• Discontinue and seek medical help if symptoms of pancreatitis (severe abdominal pain) occur

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Janvia is generally well tolerated. Common side effects may include:

• Headache

• Upper respiratory tract infection

• Nasopharyngitis

• Mild gastrointestinal discomfort

Rare but serious side effects may include pancreatitis, severe allergic reactions, or joint pain. Seek immediate medical attention if unusual symptoms develop.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.