Amloten Tablet 5 mg + 50 mg is a fixed-dose combination of Amlodipine Besilate and Atenolol, formulated to provide effective and sustained control of high blood pressure and angina. This dual-action antihypertensive medicine is particularly useful in patients who do not achieve adequate blood pressure control with single-drug therapy. By targeting different physiological pathways, Amloten helps improve cardiovascular stability and reduces the risk of serious heart-related complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Amlodipine Besilate USP: 5 mg

• Atenolol USP: 50 mg

• Dosage Form: Oral tablet

Therapeutic Class

• Calcium Channel Blocker + Cardioselective Beta-1 Adrenergic Blocker

• Antihypertensive and Antianginal agent

Indications

Amloten Tablet 5 mg + 50 mg is indicated for:

• Essential Hypertension, especially when monotherapy is insufficient

• Chronic Stable Angina Pectoris

• Patients requiring both blood pressure and heart rate control

• Reduction of cardiovascular risks such as stroke, myocardial infarction, and other hypertension-related complications

Pharmacology

Amloten Tablet combines two complementary antihypertensive agents. Amlodipine Besilate works by inhibiting calcium ion entry into vascular smooth muscle cells, leading to relaxation and dilation of peripheral arteries. This reduces systemic vascular resistance and effectively lowers blood pressure while maintaining steady blood flow.

Atenolol is a selective beta-1 adrenergic blocker that decreases heart rate, myocardial contractility, and cardiac output. It also suppresses renin release from the kidneys, contributing to additional blood pressure reduction.

The combined action results in enhanced antihypertensive and antianginal efficacy, improved myocardial oxygen balance, and sustained 24-hour control with once-daily dosing. The higher atenolol strength provides stronger heart rate control for patients who need more intensive therapy.

Dosage and Administration

• The usual recommended dose is one tablet once daily, or as directed by a physician.

• The tablet should be taken orally with water, with or without food.

• Dosage should be individualized based on patient response and clinical condition.

• Abrupt discontinuation, particularly due to the beta-blocker component, should be avoided.

Side Effects

Amloten Tablet is generally well tolerated. Possible side effects include:

• Dizziness or lightheadedness

• Fatigue or weakness

• Peripheral edema

• Bradycardia

• Cold hands or feet

• Gastrointestinal disturbances

Most side effects are mild and resolve with continued use. Medical advice should be sought if symptoms persist.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with asthma, chronic obstructive pulmonary disease, diabetes mellitus, heart block, or hepatic impairment.

• Not recommended during pregnancy or breastfeeding unless prescribed by a physician.

• Regular monitoring of blood pressure and heart rate is advised during therapy.

Drug Interactions

Amloten may interact with other antihypertensive agents, antiarrhythmics, and drugs affecting heart rate or glucose metabolism. Close monitoring is recommended when used with insulin, oral antidiabetic agents, or other cardiovascular medicines.

Storage Conditions

• Store below 30°C in a dry place

• Protect from light and moisture

• Keep out of reach of children.