Angist SR Tablet 2.6 mg contains Nitroglycerin, a well-known organic nitrate used for the prevention and long-term management of angina pectoris. The sustained-release (SR) formulation is designed to provide prolonged therapeutic action, helping to reduce the frequency of anginal attacks and improve exercise tolerance in patients with ischemic heart disease. Angist SR is intended for regular prophylactic use rather than immediate relief of acute chest pain.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Nitroglycerin

• Strength: 2.6 mg

• Dosage Form: Sustained-release oral tablet

Therapeutic Class

• Organic Nitrate

• Antianginal and Vasodilator

Indications

Angist SR Tablet 2.6 mg is indicated for:

• Prophylaxis of Angina Pectoris due to coronary artery disease

• Long-term management of chronic stable angina

• Prevention of exercise-induced or stress-related chest pain

• Supportive therapy in ischemic heart disease

Pharmacology

Nitroglycerin acts by releasing nitric oxide (NO) in vascular smooth muscle cells. Nitric oxide activates guanylate cyclase, leading to increased cyclic GMP levels, which cause relaxation of smooth muscle. This results in vasodilation of both veins and arteries.

Venous dilation reduces venous return (preload), decreasing myocardial oxygen demand, while arterial dilation lowers systemic vascular resistance (afterload). Additionally, nitroglycerin dilates coronary arteries, improving blood flow to ischemic areas of the heart. The sustained-release formulation ensures gradual drug release, maintaining effective plasma concentrations over an extended period and providing continuous angina prevention.

Dosage and Administration

• The usual dose is 2.6 mg two to three times daily, or as prescribed by a physician.

• Tablets should be swallowed whole with water and not crushed or chewed.

• To minimize nitrate tolerance, a nitrate-free interval may be recommended as part of the dosing schedule.

Side Effects

Common side effects associated with Angist SR Tablet include:

• Headache, especially at the start of therapy

• Dizziness or lightheadedness

• Flushing

• Hypotension

• Palpitations

These effects are usually dose-related and may subside with continued use.

Precautions and Warnings

• Not suitable for acute angina attacks; rapid-acting nitrates should be used for immediate relief.

• Use with caution in patients with hypotension, anemia, or increased intracranial pressure.

• Avoid abrupt postural changes to reduce the risk of dizziness or fainting.

• Not recommended during pregnancy and breastfeeding unless advised by a physician.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Angist SR should not be used with phosphodiesterase-5 inhibitors (such as sildenafil or tadalafil), as this may cause severe hypotension. Caution is advised when used with other antihypertensive medications or alcohol.

Storage Conditions

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Keep the tablets in the original container.