Aptin M Tablet 50 mg+500 mg is a combination oral antidiabetic medication containing Vildagliptin 50 mg and Metformin Hydrochloride 500 mg. This dual-action tablet is designed to help adults with type 2 diabetes mellitus achieve better blood glucose control. By combining two complementary mechanisms, it addresses both insulin secretion and insulin sensitivity, making it suitable for patients who are not adequately controlled by diet, exercise, or monotherapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredients:
  • Vildagliptin 50 mg (DPP-4 inhibitor)
  • Metformin Hydrochloride 500 mg (biguanide)

Mechanism of Action

• Vildagliptin inhibits the enzyme DPP-4, which increases levels of incretin hormones such as GLP-1 and GIP. This:
  • Enhances insulin release in response to elevated blood glucose
  • Suppresses glucagon secretion during hyperglycemia
• Metformin reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues.
• The combination helps lower fasting and postprandial blood sugar levels, providing effective glycemic control.

Indications

Aptin M Tablet 50 mg+500 mg is indicated for:

• Type 2 diabetes mellitus in adults
• Patients who do not achieve adequate glycemic control with diet, exercise, or a single oral antidiabetic drug
• Combination therapy to improve blood glucose management with a lower risk of hypoglycemia
• Long-term maintenance of blood sugar levels in type 2 diabetes

Dosage and Administration

• Adults: Typically one tablet twice daily, or as directed by a physician
• Take with meals to reduce gastrointestinal side effects from Metformin
• Swallow the tablet whole with water
• Regular monitoring of blood glucose, kidney, and liver function is recommended
• Dosage adjustments may be necessary in patients with renal or hepatic impairment

Benefits

• Combines two complementary mechanisms for improved blood sugar control
• Lowers both fasting and postprandial glucose
• Convenient oral dosing
• Reduces risk of hypoglycemia compared to insulin or sulfonylurea therapy
• Supports long-term management and adherence

Possible Side Effects

Common side effects:

• Nausea, vomiting, or diarrhea (primarily due to Metformin)
• Mild headache or dizziness
• Mild gastrointestinal discomfort

Rare but serious side effects:

• Lactic acidosis (rare, associated with Metformin)
• Hypoglycemia (especially if combined with other antidiabetic drugs)
• Allergic reactions such as rash or swelling
• Liver enzyme elevations

Precautions and Warnings

• Not for type 1 diabetes or diabetic ketoacidosis
• Use with caution in patients with kidney, liver, or heart disease
• Avoid alcohol while taking this medication due to the risk of lactic acidosis
• Inform your doctor of all medications and medical conditions
• Regular monitoring of blood glucose, renal, and hepatic function is advised

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with other antidiabetic medications, corticosteroids, or diuretics
• Use caution with medications affecting kidney or liver function
• Some contrast agents for imaging may increase the risk of lactic acidosis

Storage Instructions

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.