Araten Plus Tablet 50 mg+12.5 mg combines Losartan Potassium 50 mg and Hydrochlorothiazide 12.5 mg, offering a potent dual-action therapy for hypertension. This combination is designed for adults whose blood pressure is not adequately controlled by a single medication, providing enhanced blood pressure reduction while supporting cardiovascular and kidney health.

Losartan, an angiotensin II receptor blocker (ARB), relaxes blood vessels and reduces blood pressure by blocking the effects of angiotensin II. Hydrochlorothiazide, a thiazide diuretic, helps remove excess sodium and water through urine, further lowering blood pressure and reducing fluid retention. Together, these two agents provide a synergistic antihypertensive effect, making Araten Plus ideal for patients requiring stronger or combination therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Losartan Potassium 50 mg

• Hydrochlorothiazide 12.5 mg

Mechanism of Action

The combination works through complementary mechanisms:

1. Losartan (ARB):

   • Blocks angiotensin II receptors on blood vessels

   • Prevents vasoconstriction, lowering systemic vascular resistance

   • Reduces aldosterone secretion, decreasing sodium and water retention

2. Hydrochlorothiazide (Diuretic):

   • Increases renal excretion of sodium and water

   • Reduces blood volume and cardiac workload

   • Supports the antihypertensive effect of Losartan

This dual action ensures more effective blood pressure control than monotherapy, reducing the risk of cardiovascular complications such as heart attack, stroke, and kidney damage.

Indications

Araten Plus Tablet 50 mg+12.5 mg is indicated for:

• Hypertension (high blood pressure) not adequately controlled by monotherapy

• Patients at risk of cardiovascular events, including heart attack and stroke

• Edema or fluid retention associated with hypertension

• Renal protection in patients with hypertension and risk factors for kidney disease

Benefits

• Enhanced Blood Pressure Control: Combination therapy provides stronger antihypertensive effect

• Dual Mechanism: Addresses both vascular resistance and fluid overload

• Cardiovascular and Renal Protection: Reduces risk of heart attack, stroke, and kidney damage

• Once-Daily Dosing: Convenient tablet improves adherence

• Well-Tolerated: Generally safe under medical supervision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Typically one tablet once daily, or as prescribed by a healthcare professional

• Can be taken with or without food, preferably at the same time each day

• Shake or stir is not required as tablets are solid; swallow whole with water

• Dose adjustments may be necessary for patients with renal or hepatic impairment

• Monitor blood pressure, electrolytes, and kidney function periodically during therapy

• Do not discontinue therapy abruptly, as this may result in rebound hypertension

Safety and Precautions

• Common side effects include dizziness, headache, fatigue, or mild gastrointestinal discomfort

• Hydrochlorothiazide may cause electrolyte imbalance (low potassium or sodium)

• Rare but serious side effects may include hypotension, kidney dysfunction, or hyperkalemia

• Avoid use in pregnancy, breastfeeding, or hypersensitivity to any component

• Use caution in patients with severe kidney or liver disease

• Inform your healthcare provider of all medications and supplements to prevent interactions.