Arbitel Plus Tablet 40 mg+12.5 mg is a combination antihypertensive medication containing Telmisartan 40 mg and Hydrochlorothiazide 12.5 mg. This dual-action formulation is designed to provide effective management of high blood pressure (hypertension), particularly in patients who do not achieve adequate control with a single antihypertensive agent. By combining an angiotensin II receptor blocker (ARB) with a thiazide diuretic, Arbitel Plus helps lower blood pressure, reduce cardiovascular risk, and protect kidney function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredients:
  • Telmisartan 40 mg (Angiotensin II receptor blocker)
  • Hydrochlorothiazide 12.5 mg (Thiazide diuretic)

Mechanism of Action

• Telmisartan blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and reducing aldosterone-mediated sodium and water retention.
• Hydrochlorothiazide increases excretion of sodium and water through the kidneys, lowering blood volume and reducing blood pressure.
• The combination provides synergistic antihypertensive effects, targeting two different pathways to achieve better blood pressure control.

Indications

Arbitel Plus Tablet 40 mg+12.5 mg is indicated for:

• Management of essential hypertension in adults
• Patients not adequately controlled on monotherapy
• Reduction of cardiovascular risk, including stroke, heart attack, and heart failure
• Patients requiring combination therapy for optimal blood pressure control

Dosage and Administration

• Adults: One tablet once daily, or as prescribed by a physician
• Can be taken with or without food
• Swallow the tablet whole with water
• Regular monitoring of blood pressure, kidney function, and electrolytes is recommended
• Dosage adjustments may be needed in patients with renal or hepatic impairment

Benefits

• Dual-action therapy provides effective blood pressure reduction
• Reduces risk of cardiovascular complications such as heart attack and stroke
• Helps maintain kidney function in patients with hypertension
• Convenient once-daily dosing improves adherence
• Well-tolerated for long-term use

Possible Side Effects

Common side effects:

• Dizziness or lightheadedness
• Headache
• Fatigue
• Increased urination
• Mild gastrointestinal discomfort

Rare but serious side effects:

• Severe hypotension
• Hyperkalemia (high potassium levels)
• Electrolyte imbalances (low sodium or chloride)
• Kidney function impairment
• Allergic reactions such as rash, swelling, or angioedema

Precautions and Warnings

• Use cautiously in patients with kidney or liver disease
• Monitor electrolytes, kidney function, and blood pressure regularly
• Avoid during pregnancy, especially in the second and third trimesters
• Inform your doctor about all medications, particularly other diuretics, potassium supplements, or antihypertensives
• Not recommended in patients with a history of angioedema related to ARBs

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• Other antihypertensives – may cause excessive blood pressure lowering
• NSAIDs – may reduce antihypertensive effect or impair kidney function
• Potassium supplements – risk of hyperkalemia due to Telmisartan
• Lithium – may increase risk of lithium toxicity

Storage Instructions

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.