Arixon 1 gm/vial is a third-generation cephalosporin antibiotic for parenteral use. It is a broad-spectrum bactericidal agent effective against a wide range of Gram-positive and Gram-negative bacteria. Arixon works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. It is highly stable in the presence of beta-lactamases and has a relatively long plasma half-life (6–9 hours), which allows for convenient once- or twice-daily dosing.

Arixon is indicated for the treatment and prevention of serious bacterial infections, including respiratory tract infections, skin infections, urinary tract infections, septicemia, bone and joint infections, meningitis, gonorrhea, and perioperative prophylaxis of surgical infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Arixon 1 gm/vial is indicated for:

• Lower respiratory tract infections (pneumonia, bronchitis)

• Acute bacterial otitis media

• Skin and soft tissue infections

• Urinary tract infections

• Gonorrhea

• Bacterial septicemia

• Bone and joint infections

• Meningitis

• Prevention of postoperative infections

• Perioperative prophylaxis associated with surgery

Therapeutic Class

Third-generation cephalosporin antibiotic

Pharmacology

Arixon exhibits bactericidal activity by inhibiting bacterial cell wall synthesis. It is not metabolized and is excreted primarily unchanged in urine (40–65%) and bile. High protein binding (95%) contributes to its prolonged half-life, allowing convenient dosing.

Key Features:

• Broad-spectrum activity against Gram-positive and Gram-negative bacteria

• High stability against beta-lactamases

• Long elimination half-life enabling once- or twice-daily dosing

Dosage and Administration

Adults:

• Standard infections: 1–2 g IV or IM once daily (or in divided doses twice daily)

• Maximum: 4 g/day

• Uncomplicated gonorrhea: 250 mg IM single dose

• Surgical prophylaxis: 1 g IV 30–120 minutes before surgery

Infants and Children (≥1 month):

• General infections: 50–75 mg/kg IV or IM once daily (divided doses if needed)

• Maximum: 2 g/day

• Acute otitis media: 50 mg/kg IM single dose (max 1 g)

• Meningitis: 100 mg/kg IV or IM daily (max 4 g)

Administration Notes:

• Intramuscular: Dissolve in Lidocaine HCl 1% for pain reduction

• Intravenous: Dissolve in water for injection; administer over 2–4 minutes IV or 30 minutes via infusion

• Freshly reconstituted solution preferred (stable 6 hours at room temperature, 24 hours at 5°C)

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• No clinically significant drug interactions reported

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

Common:

• Gastrointestinal: nausea, vomiting, diarrhea, stomatitis, glossitis

• Skin: rash, pruritus, urticaria, edema, erythema multiforme

• Hematologic: eosinophilia, thrombocytopenia, leucopenia, anemia

• Hepatic: transient increases in SGOT/SGPT, bilirubinemia

Rare:

• CNS: headache, dizziness, confusion, convulsion, hyperactivity

• Local: phlebitis at IV site (minimized by slow administration)

• Anaphylaxis: may occur in sensitive patients

Precautions and Warnings

• Anaphylactic shock is possible; emergency epinephrine and glucocorticoids should be available

• Monitor blood counts during prolonged therapy

• Rare reversible gallbladder sludge may occur

Pregnancy and Lactation

• Safety in pregnancy not established; use only if clearly needed

• Low concentrations are excreted in breast milk; exercise caution

Overdose

• No specific antidote; management is symptomatic and supportive

Storage Conditions

Store vials in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.

Mode of Action

Arixon 1 gm/vial inhibits bacterial cell wall synthesis, causing bacterial lysis and death. Its broad-spectrum bactericidal activity and long half-life make it effective for severe infections and surgical prophylaxis.