Axicef Plus Tablet 250 mg+62.5 mg combines Cefuroxime Axetil 250 mg, a second-generation cephalosporin antibiotic, with Clavulanic Acid 62.5 mg, a beta-lactamase inhibitor. This combination provides a broad-spectrum antibacterial effect, making it effective against infections caused by beta-lactamase-producing bacteria that are resistant to cefuroxime alone.

Cefuroxime Axetil works by inhibiting bacterial cell wall synthesis, causing bacterial death, while Clavulanic Acid protects cefuroxime from enzymatic degradation, ensuring enhanced efficacy against resistant strains. Axicef Plus 250 mg+62.5 mg is particularly useful for mild to moderate respiratory, urinary, skin, and soft tissue infections, especially in adult and pediatric patients requiring adjusted lower doses.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Cefuroxime Axetil 250 mg

• Clavulanic Acid 62.5 mg

Mechanism of Action

The combination of Cefuroxime Axetil and Clavulanic Acid works synergistically:

1. Cefuroxime Axetil:

   • Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)

   • Causes lysis and death of susceptible bacteria

   • Effective against common Gram-positive and Gram-negative bacteria

2. Clavulanic Acid:

   • Inhibits beta-lactamase enzymes produced by resistant bacteria

   • Protects cefuroxime from degradation

   • Expands the antibacterial spectrum to include beta-lactamase-producing pathogens

This synergistic action ensures effective eradication of bacterial infections, including those caused by resistant organisms.

Indications

Axicef Plus Tablet 250 mg+62.5 mg is indicated for the treatment of:

• Respiratory tract infections: sinusitis, pharyngitis, tonsillitis, bronchitis, and mild pneumonia

• Urinary tract infections: cystitis and pyelonephritis

• Skin and soft tissue infections: cellulitis, abscesses, and wound infections

• Other mild to moderate bacterial infections caused by susceptible organisms

• Supportive therapy for infections in patients needing lower-dose treatment

Benefits

• Broad-Spectrum Antibiotic: Effective against a wide range of bacteria, including resistant strains

• Beta-Lactamase Protection: Clavulanic Acid enhances cefuroxime efficacy

• Rapid Symptom Relief: Reduces fever, inflammation, and bacterial load efficiently

• Convenient Oral Dosing: Suitable for adult and pediatric patients

• Bactericidal Action: Actively kills bacteria rather than merely inhibiting growth

• Well-Tolerated: Safe when taken as prescribed

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

• Adults and children over 12 years: One tablet every 12 hours, or as prescribed by a healthcare professional

• Tablets should be swallowed whole with water, preferably after meals to reduce gastrointestinal discomfort

• Duration of therapy typically ranges from 7–14 days, depending on the infection severity

• Complete the full course even if symptoms improve, to prevent recurrence and bacterial resistance

Safety and Precautions

• Common side effects include diarrhea, nausea, vomiting, abdominal discomfort, and mild headache

• Rare but serious effects can include allergic reactions, severe diarrhea due to Clostridium difficile, liver enzyme changes, or blood disorders

• Avoid in patients with known hypersensitivity to cephalosporins, penicillins, or Clavulanic Acid

• Use caution in patients with kidney or liver impairment, dose adjustment may be necessary

• Pregnant or breastfeeding women should use Axicef Plus only under medical supervision

• Inform your healthcare provider of all medications and supplements to avoid potential interactions.