Azactum Injection 1 gm/5 ml contains Aztreonam, a monobactam class antibiotic used to treat serious bacterial infections caused by Gram-negative bacteria. Aztreonam is particularly effective against pathogens such as Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa, making it a vital treatment option in both hospital and outpatient settings.

Azactum is commonly prescribed for infections of the respiratory tract, urinary tract, skin and soft tissues, intra-abdominal infections, and septicemia. Its intravenous (IV) or intramuscular (IM) administration allows rapid and effective delivery of the antibiotic directly into the bloodstream, ensuring prompt therapeutic action.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

How It Works

Aztreonam, the active ingredient in Azactum Injection, works by:

• Inhibiting Bacterial Cell Wall Synthesis: Binds to penicillin-binding proteins (PBPs) in Gram-negative bacteria.

• Disrupting Cell Wall Formation: Prevents cross-linking of peptidoglycan layers, weakening the bacterial cell wall.

• Bactericidal Action: Leads to bacterial cell lysis and death, effectively eliminating infection.

Aztreonam is highly selective for Gram-negative bacteria, making it less likely to disturb normal Gram-positive flora and reducing the risk of broad-spectrum resistance.

Indications

Azactum Injection 1 gm/5 ml is indicated for:

• Severe bacterial infections caused by susceptible Gram-negative organisms

• Respiratory tract infections: Pneumonia, bronchitis, and other lower respiratory infections

• Urinary tract infections: Pyelonephritis, complicated urinary infections

• Skin and soft tissue infections: Cellulitis, abscesses, and wound infections

• Intra-abdominal infections including peritonitis

• Septicemia: Bloodstream infections requiring rapid bactericidal activity

The injection is suitable for adult patients, especially those with serious infections or when oral therapy is not feasible.

Dosage and Administration

• Intravenous (IV) infusion: Typically administered over 30 minutes to 1 hour, depending on the severity of infection.

• Intramuscular (IM) injection: Can be given as an alternative when IV access is unavailable.

• Adult Dose: Usually 1–2 g every 8–12 hours depending on the infection type and severity.

• Dose adjustments may be required for patients with renal impairment.

• The duration of therapy depends on clinical response and the type of infection, as determined by the physician.

It is essential to follow the prescribed dosage and complete the full course of therapy to prevent bacterial resistance.

Benefits of Azactum Injection

• Rapidly effective against serious Gram-negative bacterial infections

• Suitable for both IV and IM administration

• Reduces the risk of complications in severe infections

• Less likely to affect Gram-positive flora, minimizing broad-spectrum side effects

• Provides an essential treatment option for patients with penicillin or cephalosporin allergies

Possible Side Effects

Azactum Injection is generally well tolerated. Common side effects may include:

• Pain or inflammation at the injection site

• Nausea, vomiting, or diarrhea

• Headache

• Rare allergic reactions including rash, itching, or anaphylaxis

• Changes in liver function tests in rare cases

Patients should seek medical attention for severe allergic reactions, persistent diarrhea, or unusual symptoms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use caution in patients with a history of hypersensitivity to β-lactam antibiotics.

• Monitor kidney function in patients with renal impairment.

• Adjust dosage in elderly patients or those with compromised renal function.

• Not recommended for viral infections as Aztreonam is ineffective against viruses.

• Inform the physician about all medications being taken to avoid drug interactions.

Storage Instructions

Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children. Once reconstituted, follow the recommended storage conditions and use promptly.

Azactum Injection 1 gm/5 ml (Aztreonam) is a potent, targeted antibiotic for the management of serious Gram-negative infections, providing rapid and effective bactericidal action when administered under medical supervision.