Betabis Plus Tablet 2.5 mg+6.25 mg is a fixed-dose combination of Bisoprolol Fumarate and Hydrochlorothiazide, formulated to provide effective and sustained control of blood pressure in patients with hypertension. By combining a cardio-selective beta-blocker with a thiazide diuretic, this tablet offers dual mechanisms that work together to lower blood pressure more efficiently than single-agent therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Bisoprolol Fumarate 2.5 mg

• Hydrochlorothiazide 6.25 mg

Therapeutic Class

• Selective beta-1 adrenergic blocker

• Thiazide diuretic

• Antihypertensive combination

Pharmacology

Bisoprolol Fumarate is a selective beta-1 adrenergic receptor blocker that primarily acts on the heart. It reduces heart rate, myocardial contractility, and cardiac output by blocking the effects of stress hormones such as adrenaline. This results in decreased blood pressure and reduced workload on the heart.

Hydrochlorothiazide is a thiazide diuretic that lowers blood pressure by increasing the excretion of sodium and water through the kidneys. This reduces plasma volume and peripheral vascular resistance, contributing to sustained antihypertensive effects.

When used together, these two agents provide complementary actions: bisoprolol controls heart rate and cardiac output, while hydrochlorothiazide helps eliminate excess fluid and sodium, leading to effective and long-lasting blood pressure control.

Indications

Betabis Plus Tablet 2.5 mg+6.25 mg is indicated for:

• Management of essential hypertension

• Patients requiring combination therapy for better blood pressure control

• Individuals not adequately controlled with monotherapy

Dosage and Administration

• The usual dose is one tablet once daily, preferably taken in the morning.

• The tablet should be swallowed whole with water and may be taken with or without food.

• Dosage adjustment should be made under medical supervision based on patient response.

• Sudden discontinuation should be avoided, especially in patients with heart disease.

Precautions and Warnings

• Use with caution in patients with renal or hepatic impairment.

• Careful monitoring is required in patients with diabetes, gout, electrolyte imbalance, or peripheral vascular disease.

• Bisoprolol may mask symptoms of hypoglycemia, while hydrochlorothiazide may alter glucose and electrolyte levels.

• Not recommended during pregnancy and breastfeeding unless clearly prescribed.

• Regular monitoring of blood pressure, kidney function, and electrolytes is advised during long-term therapy.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Some patients may experience:

• Dizziness or fatigue

• Slow heart rate

• Increased urination

• Electrolyte imbalance

• Headache or gastrointestinal discomfort

Most side effects are mild and transient. If severe reactions such as fainting, severe weakness, or dehydration occur, immediate medical attention is necessary.

Storage

• Store in a cool, dry place below 30°C.

• Protect from light and moisture.

• Keep out of reach of children.

Conclusion

Betabis Plus Tablet 2.5 mg+6.25 mg provides an effective combination approach to managing hypertension. By integrating the cardio-selective action of bisoprolol with the diuretic effect of hydrochlorothiazide, it ensures reliable blood pressure control and improved cardiovascular protection when used under proper medical guidance.